Objective We investigated the frequency of β-amyloid (Aβ) positivity in 9 groups classified
according to a combination of 3 different cognition states and 3 distinct levels of white matter …

However, an unresolved issue remains on the temporal relationship between the
development of vascular and amyloid pathologies as other potential factors, such as the …

Abstract See Cohen (doi: 10.1093/aww183) for a scientific commentary on this article.
Amyloid-β and cerebral small vessel disease are the two major causes of cognitive …

Highlights•Vascular dementia (VaD) is the second most common form of dementia, and
increases exponentially with aging of the population.•There is no pharmacologic treatment …

Background The retina and the brain share anatomic, embryologic, and physiologic
characteristics. Therefore, retinal imaging in patients with brain disorders has been of …

The presence and pattern of iron accumulation in subcortical vascular mild cognitive
impairment (svMCI) and their effects on cognition have rarely been investigated. We aimed …

Objective: To determine the independent and synergistic effects of amyloid and small vessel
disease (SVD) burden on longitudinal cognitive decline in patients with subcortical vascular …

The objective of this study was to determine whether physiological fluctuations in white
matter (PFWM) on resting-state functional magnetic resonance images could be used as an …

Inflammation is increasingly recognized as a contributor to the pathophysiology of
neuropsychiatric disorders, including depression, anxiety disorders and autism, though the …

Normal-appearing white matter (NAWM) surrounding white matter hyperintensities (WMHs),
frequently known as the WMH penumbra, is associated with subtle white matter injury and …