N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a
mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Background Malnutrition is both a frequent feature and a comorbidity of cystic fibrosis (CF),
with nutritional status strongly associated with pulmonary function and survival. Nutritional …

Chronic obstructive pulmonary disease (COPD) has become a global epidemic and is the
third leading cause of death worldwide. COPD is characterized by chronic airway …

Exposure to microgravity and ionizing radiation during spaceflight missions causes
excessive reactive oxygen species (ROS) production that contributes to cellular stress and …

Intestinal dysbiosis has been observed in children with cystic fibrosis (CF), yet the functional
consequences are poorly understood. We investigated the functional capacity of intestinal …

Background The recent global pandemic has placed a high priority on identifying drugs to
prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 …

Alterations of redox homeostasis leads to a condition of resilience known as hormesis that is
due to the activation of redox-sensitive pathways stimulating cell proliferation, growth …

Abstract The Academy of Nutrition and Dietetics Evidence Analysis Center conducted a
systematic review of the literature to develop an evidence-based practice guideline for …

Pulmonary delivery is an alternative route of administration with numerous advantages over
conventional routes of administration. It provides low enzymatic exposure, fewer systemic …