Recent advances in high-throughput molecular testing have made it possible to diagnose
most genetic disorders relatively early in gestation with minimal risk to the fetus. These …

This two-paper Series focuses on recent advances and applications of regenerative
medicine that could benefit paediatric patients. Innovations in genomic, stem-cell, and tissue …

Transplantation of allogeneic stem cells into the early gestational fetus, a treatment termed
in utero hematopoietic cell transplantation (IUHCTx), could potentially overcome the …

Autosomal dominant osteogenesis imperfecta (OI) caused by glycine substitutions in type I
collagen is a paradigmatic disorder for stem cell therapy. Bone marrow transplantation in OI …

In utero hematopoietic-cell transplantation (IUHCT) can induce donor-specific tolerance to
facilitate postnatal transplantation. Induction of tolerance requires a threshold level of mixed …

The lack of fetal immune responses to foreign antigens, ie, fetal immunologic tolerance, is
the most compelling rationale for prenatal stem cell and gene therapy. However, the …

The competence of the immune system of the developing fetus to act as a barrier to in utero
hematopoietic-cell transplantation (IUHCT) has been a source of debate. Until now …

Advances in prenatal diagnosis have led to the prenatal management and treatment of a
variety of congenital diseases. Although surgical treatment has been successfully applied to …

Evidence supporting the efficacy of in utero hematopoietic cell transplantation (IUHCT) in a
valid large animal model is needed prior to clinical application. The objective of this study …

Background. Several studies have demonstrated that bone marrow contains a
subpopulation of stem cells capable of participating in the hepatic regenerative process …