Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges

S Zhou, J Jin, J Wang, Z Zhang, JH Freedman… - Acta Pharmacologica …, 2018 - nature.com
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality in the
world. Although considerable progress has been made in the diagnosis, treatment and …

MicroRNA sequence codes for small extracellular vesicle release and cellular retention

R Garcia-Martin, G Wang, BB Brandão, TM Zanotto… - Nature, 2022 - nature.com
Exosomes and other small extracellular vesicles (sEVs) provide a unique mode of cell-to-
cell communication in which microRNAs (miRNAs) produced and released from one cell are …

miR-29b contributes to multiple types of muscle atrophy

J Li, MC Chan, Y Yu, Y Bei, P Chen, Q Zhou… - Nature …, 2017 - nature.com
A number of microRNAs (miRNAs, miRs) have been shown to play a role in skeletal muscle
atrophy, but their role is not completely understood. Here we show that miR-29b promotes …

[HTML][HTML] Oxidative stress, mitochondrial dysfunction, and respiratory chain enzyme defects in inflammatory myopathies

MG Danieli, E Antonelli, MA Piga, MF Cozzi… - Autoimmunity …, 2023 - Elsevier
We investigated the relationship between oxidative stress and inflammatory myopathies. We
searched in the current literature the role of mitochondria and respiratory chain defects as …

Physical exercise and epigenetic modifications in skeletal muscle

M Widmann, AM Nieß, B Munz - Sports medicine, 2019 - Springer
Physical activity and sports play major roles in the overall health status of humans. It is well
known that regular exercise helps to lower the risk for a broad variety of health problems …

Regulatory roles of microRNAs in diabetes

J Feng, W Xing, L Xie - International journal of molecular sciences, 2016 - mdpi.com
MicroRNAs (miRNAs), a class of endogenous small noncoding RNAs in eukaryotes, have
been recognized as significant regulators of gene expression through post-transcriptional …

Myostatin: Basic biology to clinical application

P Esposito, D Picciotto, Y Battaglia, F Costigliolo… - Advances in clinical …, 2022 - Elsevier
Myostatin is a member of the transforming growth factor (TGF)-β superfamily. It is expressed
by animal and human skeletal muscle cells where it limits muscle growth and promotes …

Cardiac dysfunction in cancer patients: beyond direct cardiomyocyte damage of anticancer drugs: novel cardio-oncology insights from the joint 2019 meeting of the …

CG Tocchetti, P Ameri, RA de Boer… - Cardiovascular …, 2020 - academic.oup.com
In western countries, cardiovascular (CV) disease and cancer are the leading causes of
death in the ageing population. Recent epidemiological data suggest that cancer is more …

Epigenetic changes in healthy human skeletal muscle following exercise–a systematic review

M Jacques, D Hiam, J Craig, R Barrès, N Eynon… - Epigenetics, 2019 - Taylor & Francis
Exercise training is continually challenging whole-body homeostasis, leading to
improvements in performance and health. Adaptations to exercise training are complex and …