Circadian clocks control the internal sleep-wake rhythmicity of 24 h which is synchronized by
the solar cycle. Circadian regulation of metabolism evolved about 2.5 billion years ago, ie …

The skin, lung, and gut are important barrier organs that control how the body reacts to
environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary …

Interleukin (IL)-33 and IL-37 have been identified as novel cytokines involved in various
inflammatory diseases. However, their specific roles remain largely unknown. Recent …

Tryptophan (Trp) is an essential amino acid that can be metabolized via endogenous and
exogenous pathways, including the Kynurenine Pathway, the 5-Hydroxyindole Pathway …

Epigenetic clocks are accurate predictors of human chronological age based on the analysis
of DNA methylation (DNAm) at specific CpG sites. However, a systematic comparison …

ABSTRACT Benzo [a] pyrene (BaP) is ubiquitously present in the aquatic environment and
has been identified as a bone toxicant. Previous studies have demonstrated that ancestral …

Kynurenine (Kyn) is a circulating tryptophan (Trp) catabolite generated by enzymes
including IDO1 that are induced by inflammatory cytokines such as interferon-gamma. Kyn …

The prognosis of systemic lupus erythematosus (SLE) is unpredictable. This study aimed to
examine the regulatory mechanism of the AHR/TET2/NT5E pathway during SLE …

Aging is a significant risk factor for various diseases, including asthma, and it often leads to
poorer clinical outcomes, particularly in elderly individuals. It is recognized that age-related …

Exposure to environmental toxicants during preconception has been shown to affect
offspring health and epigenetic mechanisms such as DNA methylation are hypothesized to …