Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Given their essential function in aerobic metabolism, mitochondria are intuitively of interest
in regard to the pathophysiology of diabetes. Qualitative, quantitative, and functional …

Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective
analgesics. To shed light on the structural basis for μOR activation, here we report a 2.1 Å X …

Reactive oxygen species (ROS) play a key role in promoting mitochondrial cytochrome c
release and induction of apoptosis. ROS induce dissociation of cytochrome c from …

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are closely linked to
degenerative diseases such as Alzheimer's disease, Parkinson's, neuronal death including …

We currently understand the mental effects of psychedelics to be caused by agonism or
partial agonism of 5-HT2A (and possibly 5-HT2C) receptors, and we understand that …

Mitochondria play an important role in controlling the life and death of a cell. Consequently,
mitochondrial dysfunction leads to a range of human diseases such as ischemia …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

It is now recognized that oxidative injury and mitochondrial dysfunction are responsible for
many clinical disorders with unmet needs, including ischemia–reperfusion injury …

Aims Free fatty acids induce apoptosis in cardiomyocytes, which is implicated in lipotoxic
cardiomyopathy. However, the underlying mechanisms remain not fully understood …