Mechanisms of estrogen influence on skeletal muscle: mass, regeneration, and mitochondrial function
A Pellegrino, PM Tiidus, R Vandenboom - Sports medicine, 2022 - Springer
Human menopause is widely associated with impaired skeletal muscle quality and
significant metabolic dysfunction. These observations pose significant challenges to the …
significant metabolic dysfunction. These observations pose significant challenges to the …
[HTML][HTML] Dysregulated systemic metabolism in a Down syndrome mouse model
Objective Trisomy 21 is one of the most complex genetic perturbations compatible with
postnatal survival. Dosage imbalance arising from the triplication of genes on human …
postnatal survival. Dosage imbalance arising from the triplication of genes on human …
CTRP13 ablation improves systemic glucose and lipid metabolism
Objective Tissue crosstalk mediated by secreted hormones underlies the integrative control
of metabolism. We previously showed that CTRP13/C1QL3, a secreted protein of the C1q …
of metabolism. We previously showed that CTRP13/C1QL3, a secreted protein of the C1q …
[HTML][HTML] Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissues
M Zhou, C Van, J Molendijk, IYY Chang, C Johnson… - Elife, 2023 - elifesciences.org
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its
dysregulation contributes to many human diseases. Beginning with the discovery of insulin …
dysregulation contributes to many human diseases. Beginning with the discovery of insulin …
Levels of Sex Hormones and Abdominal Muscle Composition in Men from The Multi-Ethnic Study of Atherosclerosis
A Osmancevic, M Allison, I Miljkovic, CA Vella… - Scientific Reports, 2024 - nature.com
Abstract Information on the associations of testosterone levels with abdominal muscle
volume and density in men is limited, while the role of estradiol and SHBG on these muscle …
volume and density in men is limited, while the role of estradiol and SHBG on these muscle …
Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues
M Zhou, I Tamburini, C Van, J Molendijk, CM Nguyen… - Elife, 2024 - elifesciences.org
Inter-organ communication is a vital process to maintain physiologic homeostasis, and its
dysregulation contributes to many human diseases. Given that circulating bioactive factors …
dysregulation contributes to many human diseases. Given that circulating bioactive factors …
[HTML][HTML] Feeding neurons integrate metabolic and reproductive states in mice
Balance between metabolic and reproductive processes is important for survival, particularly
in mammals that gestate their young. How the nervous system coordinates this balance is an …
in mammals that gestate their young. How the nervous system coordinates this balance is an …
Interplay between exercise, circadian rhythm, and cardiac metabolism and remodeling
Regular exercise improves cardiovascular and metabolic health. The beneficial effects of
exercise are influenced by several factors, including exercise intensity, biological sex, and …
exercise are influenced by several factors, including exercise intensity, biological sex, and …
Associations Between Circulating Levels of Myostatin and Plasma β-Amyloid 42/40 in a Biracial Cohort of Older Adults
Background Myostatin, a cytokine produced by skeletal muscle, may influence Alzheimer's
disease (AD) pathogenesis, but sparse evidence exists in humans. We assessed the …
disease (AD) pathogenesis, but sparse evidence exists in humans. We assessed the …
[HTML][HTML] Causal effects of serum sex hormone binding protein levels on the risk of amyotrophic lateral sclerosis: a mendelian randomization study
YN Ou, L Yang, BS Wu, L Tan, JT Yu - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background Extensive observational studies have suggested an association between serum
sex-hormone binding globulin (SHBG) and Alzheimer's disease (AD); however, causality …
sex-hormone binding globulin (SHBG) and Alzheimer's disease (AD); however, causality …