Mechanisms linking inflammation to insulin resistance

L Chen, R Chen, H Wang… - International journal of …, 2015 - Wiley Online Library
Obesity is now widespread around the world. Obesity‐associated chronic low‐grade
inflammation is responsible for the decrease of insulin sensitivity, which makes obesity a …

Emerging risk biomarkers in cardiovascular diseases and disorders

RK Upadhyay - Journal of lipids, 2015 - Wiley Online Library
Present review article highlights various cardiovascular risk prediction biomarkers by
incorporating both traditional risk factors to be used as diagnostic markers and recent …

RAGE and its ligands: molecular interplay between glycation, inflammation, and hallmarks of cancer—a review

G Palanissami, SFD Paul - Hormones and Cancer, 2018 - Springer
Risk of cancer especially of colon, breast, and pancreas is high in diabetic and obese
patients, with potential involvement of augmented expression of RAGE (receptor for …

Association between peri-implantitis and systemic inflammation: A systematic review

Y Yan, M Orlandi, J Suvan, S Harden, J Smith… - Frontiers in …, 2023 - frontiersin.org
Background Peri-implantitis is an infectious/inflammatory disease with similar clinical and
radiographic features to periodontitis. Overwhelming evidence confirmed that periodontitis …

FABP4 in macrophages facilitates obesity-associated pancreatic cancer progression via the NLRP3/IL-1β axis

J Yang, S Liu, Y Li, Z Fan, Y Meng, B Zhou, G Zhang… - Cancer Letters, 2023 - Elsevier
Obesity is an essential risk factor for pancreatic cancer (PC). Macrophage-induced
inflammation plays a pivotal role in obesity-associated carcinogenesis and disease …

Molecular mechanism with regard to the binding selectivity of inhibitors toward FABP5 and FABP7 explored by multiple short molecular dynamics simulations and free …

J Chen, X Liu, S Zhang, J Chen, H Sun… - Physical Chemistry …, 2020 - pubs.rsc.org
Recently, fatty acid binding proteins 5 and 7 (FABP5 and FABP7) have been regarded as
the prospective targets for clinically treating multiple diseases related to FABPs. In this work …

[HTML][HTML] Elevated expression of FABP3 and FABP4 cooperatively correlates with poor prognosis in non-small cell lung cancer (NSCLC)

Z Tang, Q Shen, H Xie, X Zhou, J Li, J Feng, H Liu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Fatty acid binding proteins (FABPs) are intracellular lipid-binding proteins that are involved
in a variety of biological cellular processes, including tumorigenesis. In this study, we …

GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

P De Marco, R Lappano, EMD Francesco, F Cirillo… - Scientific reports, 2016 - nature.com
Cancer-associated fibroblasts (CAFs) contribute to the malignant aggressiveness through
secreted factors like IL1β, which may drive pro-tumorigenic inflammatory phenotypes mainly …

Activation of the S100A7/RAGE pathway by IGF-1 contributes to angiogenesis in breast cancer

MG Muoio, M Talia, R Lappano, AH Sims, V Vella… - Cancers, 2021 - mdpi.com
Simple Summary Breast cancer mortality is increased in patients affected by metabolic
disorders associated with dysregulation of the Insulin-like growth factor-1 (IGF-1) axis, like …

Omentum and bone marrow: how adipocyte‐rich organs create tumour microenvironments conducive for metastatic progression

H Chkourko Gusky, J Diedrich… - Obesity …, 2016 - Wiley Online Library
A number of clinical studies have linked adiposity with increased cancer incidence,
progression and metastasis, and adipose tissue is now being credited with both systemic …