Nutrition support is increasingly recognized as a clinically relevant aspect of the intensive
care treatment of cardiac surgery patients. However, evidence from adequate large-scale …

The heart is well known as a metabolic omnivore in that it is capable of consuming fatty
acids, glucose, ketone bodies, pyruvate, lactate, amino acids and even its own constituent …

The ageing of the global population calls for a better understanding of age-related metabolic
consequences. Here we report the effects of age, sex and menopause on serum metabolites …

Importance Diabetes is associated with an elevated risk of coronary heart disease (CHD).
Previous studies have suggested that the genetic factors predisposing to excess …

Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite
improved insight into disease pathogenesis and therapeutic options, additional treatment …

Cardiovascular disease is the major cause of global mortality and disability. Abundant
evidence indicates that amino acids play a fundamental role in cardiovascular physiology …

Over the last decade, there has been a concerted clinical effort to deliver on the laboratory
promise that a variety of maneuvers can profoundly increase cardiac tolerance to ischemia …

O-GlcNAcylation is a ubiquitous and reversible post-translational protein modification that
has recently gained renewed interest due to the rapid development of analytical tools and …

Background Emerging studies have related circulating glutamine metabolites to various
chronic diseases such as cardiovascular disease and cancer; diet is the major source of …

Background rs10911021 (a single nucleotide polymorphism present upstream of the GLUL
gene) affects glutamic acid metabolism, and was shown to be associated with coronary …