Treating menopause—MHT and beyond

SR Davis, RJ Baber - Nature Reviews Endocrinology, 2022 - nature.com
Every woman who lives past midlife will experience menopause, which, by definition, is
complete cessation of ovarian function. This process might occur spontaneously (natural …

[HTML][HTML] Alzheimer's disease: risk factors and potentially protective measures

MVF Silva, CMG Loures, LCV Alves… - Journal of biomedical …, 2019 - Springer
Alzheimer's disease (AD) is the most common type of dementia and typically manifests
through a progressive loss of episodic memory and cognitive function, subsequently causing …

The 2022 hormone therapy position statement of the North American Menopause Society

SS Faubion, CJ Crandall, L Davis… - …, 2022 - ingentaconnect.com
“The 2022 Hormone Therapy Position Statement of The North American Menopause
Society”(NAMS) updates “The 2017 Hormone Therapy Position Statement of The North …

[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

Y Yan, X Wang, D Chaput, MK Shin, Y Koh, L Gan… - Cell, 2022 - cell.com
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Understanding the impact of sex and gender in Alzheimer's disease: a call to action

RA Nebel, NT Aggarwal, LL Barnes, A Gallagher… - Alzheimer's & …, 2018 - Elsevier
Introduction Precision medicine methodologies and approaches have advanced our
understanding of the clinical presentation, development, progression, and management of …

Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Defeating Alzheimer's disease and other dementias: a priority for European science and society

B Winblad, P Amouyel, S Andrieu, C Ballard… - The Lancet …, 2016 - thelancet.com
Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

[HTML][HTML] Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European …

RNM Saleh, M Hornberger, CW Ritchie… - Alzheimer's research & …, 2023 - Springer
Background The risk of dementia is higher in women than men. The metabolic
consequences of estrogen decline during menopause accelerate neuropathology in …

Management of menopause: a view towards prevention

RA Lobo, A Gompel - The Lancet Diabetes & Endocrinology, 2022 - thelancet.com
Women spend approximately one-third of their lives with menopause, which occurs around
50 years of age. It is now appreciated that several important metabolic and cardiovascular …

[HTML][HTML] Menopausal hormone therapy and long-term all-cause and cause-specific mortality: the Women's Health Initiative randomized trials

JAE Manson, AK Aragaki, JE Rossouw, GL Anderson… - Jama, 2017 - jamanetwork.com
Importance Health outcomes from the Women's Health Initiative Estrogen Plus Progestin
and Estrogen-Alone Trials have been reported, but previous publications have generally not …