Minimal residual disease (MRD) is the most important independent prognostic factor in
acute lymphoblastic leukemia (ALL). Since it has been implemented into in treatment …

Immune responses play a critical role in various disease conditions including cancer and
autoimmune diseases. However, to date, there has not been a rapid, sensitive …

Abstract Background V (D) J recombinations in lymphocytes are essential for immunological
diversity. They are also useful markers of pathologies. In leukemia, they are used to quantify …

Recent advances in high-throughput single cell sequencing have opened up new avenues
into the investigation of B cell receptor (BCR) repertoires. In this study, PBMCs were …

With the advent of high-throughput sequencing of immunoglobulin genes (Ig-Seq), the
understanding of antibody repertoires and their dynamics among individuals and …

Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin
changes (POEMS) syndrome is a rare multisystem disease resulting from an underlying …

The adaptive immune response is a powerful tool, capable of recognizing, binding to, and
neutralizing a vast number of internal and external threats via T or B lymphatic receptors with …

Intraclonal diversification (ID) within the immunoglobulin (IG) genes expressed by B cell
clones arises due to ongoing somatic hypermutation (SHM) in a context of continuous …

Background The study of human B cell response to dengue virus (DENV) infection is critical
to understand serotype-specific protection and the cross-reactive sub-neutralizing response …

High-throughput sequencing has recently been applied to profile the high diversity of
antibodyome/B cell receptors (BCRs) and T cell receptors (TCRs) among immune cells. To …