B cell receptors (BCRs) and T cell receptors (TCRs) make up an essential network of
defense molecules that, collectively, can distinguish self from non-self and facilitate …

Abstract γδ T cells are a relatively rare subset of lymphocytes in the human peripheral blood,
but they play important roles at the interface between the innate and the adaptive immune …

High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability
to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously …

High-throughput sequencing (HTS) of antibody repertoire libraries has become a powerful
tool in the field of systems immunology. However, numerous sources of bias in HTS …

The ability of T lymphocytes to mount an immune response against a diverse array of
pathogens is primarily conveyed by the amino acid (aa) sequence of the hypervariable …

Previous work from our group and others has shown that patients with breast cancer can
generate a T cell response against specific human epidermal growth factor 2 (HER2) …

Exposure to multiple mosquito-borne flaviviruses within a lifetime is not uncommon;
however, how sequential exposures to different flaviviruses shape the cross-reactive …

Transforming error-prone immunosequencing datasets into Ab repertoires is a fundamental
problem in immunogenomics, and a prerequisite for studies of immune responses. Although …

Neutralizing antibodies (nAbs) to highly variable viral pathogens show remarkable
diversification during infection, resulting in an" arms race" between virus and host. Studies of …

New high‐throughput DNA sequencing (HTS) technologies developed in the past decade
have rapidly increased the scale of data collection for all aspects of human genetics (1, 2) …