Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or …

In this review, we examine the fungal spore killers. These are meiotic drive elements that
cheat during sexual reproduction to increase their transmission into the next generation …

Spermatogenesis is a highly regulated process that produces sperm to transmit genetic
information to the next generation. Although extensively studied in mice, our current …

Hybrid sterility restricts the utilization of superior heterosis of indica-japonica inter-
subspecific hybrids. In this study, we report the identification of RHS12, a major locus …

Meiotic drivers are a class of selfish genetic elements whose existence is frequently hidden
due to concomitant suppressor systems. Accordingly, we know little of their evolutionary …

Meiotic drivers are selfish elements that bias their own transmission into more than half of
the viable progeny produced by a driver+/driver− heterozygote. Meiotic drivers are thought …

Selfish genetic elements use a myriad of mechanisms to drive their inheritance and ensure
their survival into the next generation, often at a fitness cost to its host. 1, 2 Although the …

Meiotic drive loci distort the normally equal segregation of alleles, which benefits their own
transmission even in the face of severe fitness costs to their host organism. However …

The mammalian sex chromosomes harbor an abundance of newly acquired ampliconic
genes, although their functions require elucidation [1–9]. Here, we demonstrate that the X …

Centromeres connect chromosomes and spindle microtubules to ensure faithful
chromosome segregation. Paradoxically, despite this conserved function, centromeric DNA …