Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

NOD-like receptor (NLR), family pyrin domain containing 3 (NLRP3) assembles a protein
complex known as the NLRP3 inflammasome upon sensing certain pathogen products or …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

The morbidity and mortality of autoimmune diseases (Ads) have been increasing worldwide,
and the identification of novel therapeutic strategies for prevention and treatment is urgently …

Background Neuroinflammation and immune responses occurring minutes to hours after
stroke are associated with brain injury after acute ischemic stroke (AIS). PPARγ coactivator …

Relevant reviews highlight the association between dysfunctional mitochondria and
inflammation, but few studies address the contribution of mitochondria and mitochondria …

The role of the cytokines and receptors of the IL-1 family in inflammation is well known.
Several cytokines of the family have a powerful inflammatory activity, with IL-1β being the …

NOD-like receptor protein 3 (NLRP3), an important intracellular pattern recognition receptor,
is a component of the NLRP3 inflammasome along with apoptosis-associated speck-like …

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates
with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 …