Quantitative phase imaging in biomedicine

YK Park, C Depeursinge, G Popescu - Nature photonics, 2018 - nature.com
Quantitative phase imaging (QPI) has emerged as a valuable method for investigating cells
and tissues. QPI operates on unlabelled specimens and, as such, is complementary to …

[HTML][HTML] Quantitative phase imaging techniques for the study of cell pathophysiology: from principles to applications

KR Lee, K Kim, J Jung, JH Heo, S Cho, S Lee… - Sensors, 2013 - mdpi.com
A cellular-level study of the pathophysiology is crucial for understanding the mechanisms
behind human diseases. Recent advances in quantitative phase imaging (QPI) techniques …

[HTML][HTML] Gradient light interference microscopy for 3D imaging of unlabeled specimens

TH Nguyen, ME Kandel, M Rubessa… - Nature …, 2017 - nature.com
Multiple scattering limits the contrast in optical imaging of thick specimens. Here, we present
gradient light interference microscopy (GLIM) to extract three-dimensional information from …

White-light diffraction tomography of unlabelled live cells

T Kim, R Zhou, M Mir, SD Babacan, PS Carney… - Nature …, 2014 - nature.com
We present a technique called white-light diffraction tomography (WDT) for imaging
microscopic transparent objects such as live unlabelled cells. The approach extends …

Roadmap on Label‐Free Super‐Resolution Imaging

VN Astratov, YB Sahel, YC Eldar… - Laser & Photonics …, 2023 - Wiley Online Library
Label‐free super‐resolution (LFSR) imaging relies on light‐scattering processes in
nanoscale objects without a need for fluorescent (FL) staining required in super‐resolved FL …

Quantitative phase imaging

M Mir, B Bhaduri, R Wang, R Zhu, G Popescu - Progress in optics, 2012 - Elsevier
Quantitative phase imaging (QPI) is an emerging field aimed at studying weakly scattering
and absorbing specimens (Popescu, 2011). The main challenge in generating intrinsic …

Quantitative phase imaging for medical diagnosis

H Majeed, S Sridharan, M Mir, L Ma, E Min… - Journal of …, 2017 - Wiley Online Library
Optical microscopy is an indispensable diagnostic tool in modern healthcare. As a prime
example, pathologists rely exclusively on light microscopy to investigate tissue morphology …

[HTML][HTML] Viewing life without labels under optical microscopes

B Ghosh, K Agarwal - Communications Biology, 2023 - nature.com
Optical microscopes today have pushed the limits of speed, quality, and observable space in
biological specimens revolutionizing how we view life today. Further, specific labeling of …

[HTML][HTML] Viscoelasticity, like forces, plays a role in mechanotransduction

CT Mierke - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Viscoelasticity and its alteration in time and space has turned out to act as a key element in
fundamental biological processes in living systems, such as morphogenesis and motility …

Spatial light interference microscopy: principle and applications to biomedicine

X Chen, ME Kandel, G Popescu - Advances in optics and photonics, 2021 - opg.optica.org
In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-
shifting interferometer, built onto a phase-contrast microscope, with white-light illumination …