Glaucoma is one of the leading causes of vision impairment worldwide. In order to further
understand the molecular pathobiology of this disease and to develop better therapies …

Introduction: Aqueous humor and its dynamics (AHD) serve numerous functions to sustain
ocular health and clear vision. Current methods to assess AHD have led to improved …

A reliable animal model providing chronic and persistent ocular hypertension and
characteristic neurodegeneration is essential to recapitulate human glaucoma and …

Measurement of intraocular pressure (IOP) is a standard procedure in ophthalmic research
in animals, specifically in glaucoma research, and the control of IOP is essential during …

Purpose: To compare the effects of both injectable anesthesia (ketamine/dexmedetomidine
versus ketamine/xylazine) and inhalant anesthesia (isoflurane) on IOP using continuous …

Purpose The elevation of intraocular pressure (IOP), a major risk factor in glaucoma, is an
important parameter tracked in experimental models of this disease. However, IOP …

Background Disclosing the mechanism of primary angle closure glaucoma with pupillary
block is important to the diagnosis as well as treatments, such as the laser peripheral …

Discovery ophthalmic research is centered around delineating the molecular and cellular
basis of ocular diseases and finding and exploiting molecular and genetic pathways …

Purpose: To evaluate the effect of ATP-sensitive potassium channel openers cromakalim
prodrug 1 (CKLP1) and diazoxide on IOP in three independent mouse models of ocular …

Elevated intraocular pressure (IOP) has been considered to be the major risk factor for
glaucoma. The trabecular meshwork (TM), serving as the primary outflow pathway of …