Decades of advancements in immuno-oncology have enabled the development of current
immunotherapies, which provide long-term treatment responses in certain metastatic cancer …

Inflammation is an integral part of autoimmune diseases, which are caused by dysregulation
of the immune system. This dysregulation involves an imbalance between pro-inflammatory …

Multiple sclerosis (MS) is a common degenerative disorder of the central nervous system.
The decreased frequency and dysfunction of Treg cells cause inflammation and disease …

Multiple sclerosis (MS) is a neurologic disease affecting myelinated nerves in the central
nervous system (CNS). The disease often debuts as a clinically isolated syndrome, eg, optic …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

The immune system ensures optimum T-effector (Teff) immune responses against invading
microbes and tumor antigens while preventing inappropriate autoimmune responses …

Silybum marianum (SM), a well-known plant used as both a medicine and a food, has been
widely used to treat various diseases, especially hepatic diseases. The seeds and fruits of …

Regulatory (Treg) cells are key regulators of inflammation and important for immune
tolerance and homeostasis. A major progress has been made in the identification and …

Autoimmune diseases (ADs) are characterized by the production of autoreactive
lymphocytes, immune responses to self-antigens, and inflammation in related tissues and …

CNS inflammation is a major driver of MS pathology. Differential immune responses,
including the adaptive and the innate immune system, are observed at various stages of MS …