Propagation-based phase-contrast X-ray imaging at a compact light source

R Gradl, M Dierolf, L Hehn, B Günther, AÖ Yildirim… - Scientific reports, 2017 - nature.com
We demonstrate the applicability of propagation-based X-ray phase-contrast imaging at a
laser-assisted compact light source with known phantoms and the lungs and airways of a …

[PDF][PDF] Methods for dynamic synchrotron X-ray respiratory imaging in live animals

KS Morgan, D Parsons, P Cmielewski… - Journal of …, 2020 - journals.iucr.org
Small-animal physiology studies are typically complicated, but the level of complexity is
greatly increased when performing live-animal X-ray imaging studies at synchrotron and …

Dynamic In Vivo Chest X-ray Dark-Field Imaging in Mice

R Gradl, KS Morgan, M Dierolf, C Jud… - IEEE transactions on …, 2018 - ieeexplore.ieee.org
X-ray grating interferometry is a powerful emerging tool in biomedical imaging, providing
access to three complementary image modalities. In addition to the conventional attenuation …

[HTML][HTML] In vivo dynamic phase-contrast X-ray imaging using a compact light source

R Gradl, M Dierolf, B Günther, L Hehn, W Möller… - Scientific Reports, 2018 - nature.com
We describe the first dynamic and the first in vivo X-ray imaging studies successfully
performed at a laser-undulator-based compact synchrotron light source. The X-ray …

A review of small animal dosimetry techniques: image-guided and spatially fractionated therapy

CD Johnstone, M Bazalova-Carter - Journal of Physics …, 2023 - iopscience.iop.org
Research in small animal radiotherapy is a crucial step in clinical translation of novel
radiotherapy techniques, either delivered as stand-alone treatment or in combination with …

In Vivo X-Ray Imaging Reveals Improved Airway Surface Hydration after a Therapy Designed for Cystic Fibrosis

KS Morgan, M Donnelley, N Farrow… - American journal of …, 2014 - atsjournals.org
Sufficient airway surface liquid (ASL) depth is critical to ensure that the mucociliary transport
system can effectively clear inhaled pathogens from the lungs. In those with cystic fibrosis …

Non-invasive airway health assessment: Synchrotron imaging reveals effects of rehydrating treatments on mucociliary transit in-vivo

M Donnelley, KS Morgan, KKW Siu, NR Farrow… - Scientific reports, 2014 - nature.com
To determine the efficacy of potential cystic fibrosis (CF) therapies we have developed a
novel mucociliary transit (MCT) measurement that uses synchrotron phase contrast X-ray …

Noncontact respiratory motion detection in anesthetized rodents

M Donnelley, L Lagerquist… - Journal of the …, 2023 - ingentaconnect.com
Small animal physiology studies are often complicated, but the level of complexity is greatly
increased when performing live-animal X-ray imaging studies at synchrotron radiation …

Synchrotron phase-contrast X-ray imaging reveals fluid dosing dynamics for gene transfer into mouse airways

M Donnelley, KKW Siu, RA Jamison, DW Parsons - Gene therapy, 2012 - nature.com
Although airway gene transfer research in mouse models relies on bolus fluid dosing into
the nose or trachea, the dynamics and immediate fate of delivered gene transfer agents are …

Dry deposition of pollutant and marker particles onto live mouse airway surfaces enhances monitoring of individual particle mucociliary transit behaviour

M Donnelley, KS Morgan, KKW Siu… - Journal of synchrotron …, 2012 - journals.iucr.org
Particles suspended in the air are inhaled during normal respiration and unless cleared by
airway defences, such as the mucociliary transit (MCT) system, they can remain and affect …