[HTML][HTML] Advances in tissue engineering and innovative fabrication techniques for 3-D-structures: translational applications in neurodegenerative diseases

F Rey, B Barzaghini, A Nardini, M Bordoni, GV Zuccotti… - Cells, 2020 - mdpi.com
In the field of regenerative medicine applied to neurodegenerative diseases, one of the most
important challenges is the obtainment of innovative scaffolds aimed at improving the …

[HTML][HTML] Fostering mesenchymal stem cell therapy to halt cytokine storm in COVID-19

M Jeyaraman, A John, S Koshy, R Ranjan… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) has been threatening the globe since
the end of November 2019. The disease revealed cracks in the health care system as health …

[HTML][HTML] Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity

C Lefebvre-Omar, E Liu, C Dalle, BL d'Incamps… - Cellular and Molecular …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …

[HTML][HTML] Umbilical cord mesenchymal stem cells in amyotrophic lateral sclerosis: an original study

M Barczewska, S Maksymowicz… - Stem Cell Reviews and …, 2020 - Springer
Objective Amyotrophic lateral sclerosis (ALS) is still incurable. Although different therapies
can affect the health and survival of patients. Our aim is to evaluate the effect of umbilical …

[HTML][HTML] Expression of endogenous angiotensin-converting enzyme 2 in human induced pluripotent stem cell-derived retinal organoids

HI Ahmad Mulyadi Lai, SJ Chou, Y Chien… - International Journal of …, 2021 - mdpi.com
Angiotensin-converting enzyme 2 (ACE2) was identified as the main host cell receptor for
the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its …

[HTML][HTML] Mini-Review: Induced pluripotent stem cells and the search for new cell-specific ALS therapeutic targets

L Ferraiuolo, NJ Maragakis - Neuroscience letters, 2021 - Elsevier
Amongst the most important discoveries in ALS pathobiology are the works demonstrating
that multiple cell types contribute to disease onset and progression. However, a significant …

[HTML][HTML] Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

B Arjmand, S Kokabi Hamidpour, Z Rabbani… - Frontiers in …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis is a pernicious neurodegenerative disorder that is associated
with the progressive degeneration of motor neurons, the disruption of impulse transmission …

[HTML][HTML] Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics

D Ramsden, DG Belair, S Agarwal… - ALTEX-Alternatives to …, 2022 - altex.org
Oligonucleotide therapeutics (ONTs) encompass classes of medicines that selectively target
and potentially ameliorate previously untreatable and often rare diseases. Several unique …

Small molecules targeting different cellular pathologies for the treatment of amyotrophic lateral sclerosis

MF Elmansy, CT Reidl, M Rahaman… - Medicinal Research …, 2023 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease in which the
motor neuron circuitry displays progressive degeneration, affecting mostly the motor …

[HTML][HTML] In vitro 3D modeling of neurodegenerative diseases

A Louit, T Galbraith, F Berthod - Bioengineering, 2023 - mdpi.com
The study of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's
disease, Huntington's disease, or amyotrophic lateral sclerosis) is very complex due to the …