Oxidative stress develops as a response to injury and reflects a breach in the cell's
antioxidant capacity. Therefore, the fine-tuning of reactive oxygen species (ROS) generation …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

Mitochondrial permeability transition, as the consequence of opening of a mitochondrial
permeability transition pore (mPTP), is a cellular catastrophe. Initiating bioenergetic collapse …

Reactive oxygen species (ROS) play a key signaling role in plant and animal cells. Among
the many cellular mechanisms used to generate and transduce ROS signals, ROS-induced …

In aging and neurodegenerative diseases, loss of distinct type of neurons characterizes
disease-specific pathological and clinical features, and mitochondria play a pivotal role in …

It is well-known that mitochondrial DNA (mtDNA) can escape to intracellular or extracellular
compartments under different stress conditions, yet understanding their escape mechanisms …

Recent evidence highlights that the cancer cell energy requirements vary greatly from
normal cells and that cancer cells exhibit different metabolic phenotypes with variable …

Over the past 30 years the mitochondrial permeability transition–the permeabilization of the
inner mitochondrial membrane due to the opening of a wide pore–has progressed from …

Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its
antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range …

Much is known, but there is also much more to discover, about the actions that thyroid
hormones (TH) exert on metabolism. Indeed, despite the fact that thyroid hormones are …