The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …

Metabolic inhibitors have been used in oncology for decades, dating back to antimetabolites
developed in the 1940s. In the past 25 years, there has been increased recognition of …

The polyamines putrescine, spermidine, and spermine are abundant polycations of vital
importance in mammalian cells. Their cellular levels are tightly regulated by degradation …

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the
most lethal of childhood cancers. Palliative radiotherapy is the only established treatment …

Cancer cells are addictive to exogenous methionine to gear toward tumor proliferation.
Meanwhile, they can replenish methionine pool from polyamine metabolism through a …

Polyamines are ubiquitous, amine-rich molecules with diverse processes in biology. Recent
work has highlighted that polyamines exert profound roles on the mammalian immune …

Targeting ferroptosis, an iron-dependent form of regulated cell death triggered by the lethal
overload of lipid peroxides, in cancer therapy is impeded by our limited understanding of the …

Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

Diffuse midline gliomas (DMGs) bearing driver mutations of histone 3 lysine 27 (H3K27M)
are incurable brain tumors with unique epigenomes. Here, we generated a syngeneic …

Simple Summary H3K27M-mutant diffuse midline glioma is a rare childhood cancer
originating in midline brain structures. The H3K27M mutation substitutes an amino acid on …