[HTML][HTML] 3D genomic features across> 50 diverse cell types reveal insights into the genomic architecture of childhood obesity
The prevalence of childhood obesity is increasing worldwide, along with the associated
common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated …
common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated …
[HTML][HTML] Dietary and genetic determinants of non-alcoholic fatty liver disease in coronary heart disease patients
L Heerkens, JM Geleijnse… - European Journal of …, 2024 - Springer
Purpose A healthy diet reduces the risk of non-alcoholic fatty liver disease (NAFLD) in the
general population, especially in individuals who are genetically predisposed to NAFLD …
general population, especially in individuals who are genetically predisposed to NAFLD …
[HTML][HTML] Observational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease
QY Hao, YH Zeng, Y Lin, JB Guo, SC Li… - Frontiers in …, 2024 - frontiersin.org
Background Non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant driver
of chronic liver disease globally and is associated with increased cardiovascular disease …
of chronic liver disease globally and is associated with increased cardiovascular disease …
An adult‐based genetic risk score for liver fat associates with liver and plasma lipid traits in children and adolescents
Abstract Background & Aims Genome‐wide association studies have identified steatogenic
variants that also showed pleiotropic effects on cardiometabolic traits in adults. We …
variants that also showed pleiotropic effects on cardiometabolic traits in adults. We …
Epigenetic Alterations in Alzheimer's Disease: Impact on Insulin Signaling and Advanced Drug Delivery Systems
Simple Summary This review mainly focuses on epigenetic changes in a few selective
genes associated with insulin insensitivity in the periphery and how this peripheral insulin …
genes associated with insulin insensitivity in the periphery and how this peripheral insulin …
Pitfalls in performing genome-wide association studies on ratio traits
Genome-wide association studies (GWAS) are often performed on ratios composed of a
numerator trait divided by a denominator trait. Examples include body mass index (BMI) and …
numerator trait divided by a denominator trait. Examples include body mass index (BMI) and …
[HTML][HTML] Clinical and genetic risk factors for progressive fibrosis in metabolic dysfunction–associated steatotic liver disease
DE Kaplan, CC Teerlink… - Hepatology …, 2024 - journals.lww.com
Background: Fibrosis-4 (FIB4) is a recommended noninvasive test to assess hepatic fibrosis
among patients with metabolic dysfunction–associated steatotic liver disease (MASLD) …
among patients with metabolic dysfunction–associated steatotic liver disease (MASLD) …
[HTML][HTML] The contribution of genetics and epigenetics to MAFLD susceptibility
V Moretti, S Romeo, L Valenti - Hepatology International, 2024 - Springer
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver
disease worldwide. The risk of developing MAFLD varies among individuals, due to a …
disease worldwide. The risk of developing MAFLD varies among individuals, due to a …
[HTML][HTML] Residential green and blue spaces with nonalcoholic fatty liver disease incidence: Mediating effect of air pollutants
M Liu, S Yang, Z Ye, Y Zhang, P He, C Zhou… - Ecotoxicology and …, 2023 - Elsevier
Background This study aimed to investigate the relationship of residential green and blue
spaces with incident nonalcoholic fatty liver disease (NAFLD), and explore the potential …
spaces with incident nonalcoholic fatty liver disease (NAFLD), and explore the potential …
[HTML][HTML] Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer
Background The underlying mechanisms for the link between steatotic liver disease and
cardiovascular and cancer outcomes are poorly understood. We aimed to use MRI-derived …
cardiovascular and cancer outcomes are poorly understood. We aimed to use MRI-derived …