[HTML][HTML] 3D genomic features across> 50 diverse cell types reveal insights into the genomic architecture of childhood obesity

KB Trang, MC Pahl, JA Pippin, C Su, SH Littleton… - medRxiv, 2024 - ncbi.nlm.nih.gov
The prevalence of childhood obesity is increasing worldwide, along with the associated
common comorbidities of type 2 diabetes and cardiovascular disease in later life. Motivated …

[HTML][HTML] Dietary and genetic determinants of non-alcoholic fatty liver disease in coronary heart disease patients

L Heerkens, JM Geleijnse… - European Journal of …, 2024 - Springer
Purpose A healthy diet reduces the risk of non-alcoholic fatty liver disease (NAFLD) in the
general population, especially in individuals who are genetically predisposed to NAFLD …

[HTML][HTML] Observational and genetic association of non-alcoholic fatty liver disease and calcific aortic valve disease

QY Hao, YH Zeng, Y Lin, JB Guo, SC Li… - Frontiers in …, 2024 - frontiersin.org
Background Non-alcoholic fatty liver disease (NAFLD) has emerged as a predominant driver
of chronic liver disease globally and is associated with increased cardiovascular disease …

An adult‐based genetic risk score for liver fat associates with liver and plasma lipid traits in children and adolescents

Y Huang, SE Stinson, HB Juel, MAV Lund… - Liver …, 2023 - Wiley Online Library
Abstract Background & Aims Genome‐wide association studies have identified steatogenic
variants that also showed pleiotropic effects on cardiometabolic traits in adults. We …

Epigenetic Alterations in Alzheimer's Disease: Impact on Insulin Signaling and Advanced Drug Delivery Systems

A Greeny, A Nair, P Sadanandan, S Satarker… - Biology, 2024 - mdpi.com
Simple Summary This review mainly focuses on epigenetic changes in a few selective
genes associated with insulin insensitivity in the periphery and how this peripheral insulin …

Pitfalls in performing genome-wide association studies on ratio traits

ZR McCaw, R Dey, H Somineni, D Amar, S Mukherjee… - bioRxiv, 2023 - biorxiv.org
Genome-wide association studies (GWAS) are often performed on ratios composed of a
numerator trait divided by a denominator trait. Examples include body mass index (BMI) and …

[HTML][HTML] Clinical and genetic risk factors for progressive fibrosis in metabolic dysfunction–associated steatotic liver disease

DE Kaplan, CC Teerlink… - Hepatology …, 2024 - journals.lww.com
Background: Fibrosis-4 (FIB4) is a recommended noninvasive test to assess hepatic fibrosis
among patients with metabolic dysfunction–associated steatotic liver disease (MASLD) …

[HTML][HTML] The contribution of genetics and epigenetics to MAFLD susceptibility

V Moretti, S Romeo, L Valenti - Hepatology International, 2024 - Springer
Metabolic dysfunction-associated fatty liver disease (MAFLD) is the most common liver
disease worldwide. The risk of developing MAFLD varies among individuals, due to a …

[HTML][HTML] Residential green and blue spaces with nonalcoholic fatty liver disease incidence: Mediating effect of air pollutants

M Liu, S Yang, Z Ye, Y Zhang, P He, C Zhou… - Ecotoxicology and …, 2023 - Elsevier
Background This study aimed to investigate the relationship of residential green and blue
spaces with incident nonalcoholic fatty liver disease (NAFLD), and explore the potential …

[HTML][HTML] Differing genetic variants associated with liver fat and their contrasting relationships with cardiovascular diseases and cancer

A Ahmed, M Cule, JD Bell, N Sattar, H Yaghootkar - Journal of Hepatology, 2024 - Elsevier
Background The underlying mechanisms for the link between steatotic liver disease and
cardiovascular and cancer outcomes are poorly understood. We aimed to use MRI-derived …