Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Targeting immune checkpoints such as programmed cell death protein 1 (PD1),
programmed cell death 1 ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has …

Human milk oligosaccharides (HMOs) comprise a group of structurally complex,
unconjugated glycans that are highly abundant in human milk. HMOs are minimally digested …

Galectins are a family of animal lectins with diverse biological activities. They function both
extracellularly, by interacting with cell-surface and extracellular matrix glycoproteins and …

The ability of natural metalloproteins to prevent inactivation of their metal cofactors by
biological metabolites, such as glutathione, is an area that has been largely ignored in the …

Galectin-3 is unique among the galectin family of animal lectins in its biological activities and
structure. Most members of the galectin family including galectin-1 possess apoptotic …

Growing insights into the many roles of glycoconjugates in biorecognition as ligands for
lectins indicates a need to compare plant and animal lectins. Furthermore, the popularity of …

Despite the existence of tumor-specific immune cells, most tumors have devised strategies
to avoid immune attack. We demonstrate here that galectin-1 (Gal-1), a negative regulator of …

Recent evidence has implicated galectins and their ligands as master regulators of immune
cell homeostasis. Whereas some members of this family, such as galectin-3, behave as …

Mucins are high-molecular weight epithelial glycoproteins with a high content of clustered
oligosaccharides O-glycosidically linked to tandem repeat peptides rich in threonine, serine …