[HTML][HTML] EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review

OWG Wood, JHY Yeung, RLM Faull… - Frontiers in …, 2022 - frontiersin.org
Glutamate is the main excitatory neurotransmitter in the human central nervous system,
responsible for a wide variety of normal physiological processes. Glutamatergic metabolism …

Proteinopathies: deciphering physiology and mechanisms to develop effective therapies for neurodegenerative diseases

G Chopra, S Shabir, S Yousuf, S Kauts, SA Bhat… - Molecular …, 2022 - Springer
Neurodegenerative diseases (NDs) are a cluster of diseases marked by progressive
neuronal loss, axonal transport blockage, mitochondrial dysfunction, oxidative stress …

Efficacy and tolerability of olive oil-based ketogenic diet in children with drug-resistant epilepsy: A single center experience from Turkey

O Guzel, U Uysal, N Arslan - european journal of paediatric neurology, 2019 - Elsevier
Purpose Ketogenic diet (KD) is an effective non-pharmacological treatment for drug-resistant
epilepsy. The aim of this study was to investigate the efficacy, tolerability and complications …

Novel olive oil phenolic (−)-oleocanthal (+)-xylitol-based solid dispersion formulations with potent oral anti-breast cancer activities

MH Qusa, AB Siddique, S Nazzal… - International journal of …, 2019 - Elsevier
Epidemiological studies have compellingly documented the ability of the Mediterranean diet
rich in extra-virgin olive oil to reduce the incidence of certain malignancies, and …

Role of the ketogenic diet in acute neurological diseases

N Arora, TR Mehta - Clinical Neurology and Neurosurgery, 2020 - Elsevier
The current review outlines the role of ketogenic diet (KD) in the management of acute
neurological conditions namely traumatic brain injury, ischemic stroke, status epilepticus …

[HTML][HTML] Does diet have a role in the treatment of Alzheimer's disease?

M Thelen, HM Brown-Borg - Frontiers in aging neuroscience, 2020 - frontiersin.org
The aging process causes many changes to the brain and is a major risk factor for the
development of neurodegenerative diseases such as Alzheimer's Disease (AD). Despite an …

Upregulation of thioredoxin-interacting protein in brain of amyloid-β protein precursor/presenilin 1 transgenic mice and amyloid-β treated neuronal cells

Y Wang, Y Wang, V Bharti, H Zhou… - Journal of …, 2019 - content.iospress.com
Oxidative stress has been hypothesized to play a role in the pathophysiology of Alzheimer's
disease (AD). Previously, we found that total nitrosylated protein levels were increased in …

Natural molecules for healthy lifestyles: Oleocanthal from extra virgin olive oil

V Francisco, C Ruiz-Fernández, V Lahera… - Journal of agricultural …, 2019 - ACS Publications
Extra virgin olive oil (EVOO) is the main source of fat in the Mediterranean diet. Phenolic
compounds of EVOO, in particular, secoiridoids, are minor components that have generated …

[HTML][HTML] (−)-Oleocanthal prevents breast cancer locoregional recurrence after primary tumor surgical excision and neoadjuvant targeted therapy in orthotopic nude …

AB Siddique, NM Ayoub, A Tajmim, SA Meyer, RA Hill… - Cancers, 2019 - mdpi.com
Breast cancer (BC) recurrence represents a challenge for survivors who have had their
primary tumors surgically excised, and/or have completed radiation, neoadjuvant, or …

Glutamate metabolism in mitochondria is closely related to alzheimer's disease

J Song, X Yang, M Zhang, C Wang… - Journal of Alzheimer's …, 2021 - content.iospress.com
Glutamate is the main excitatory neurotransmitter in the brain, and its excitatory neurotoxicity
is closely related to the occurrence and development of Alzheimer's disease. However …