The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

S Lukhele, D Abd Rabbo, M Guo, J Shen, HJ Elsaesser… - Immunity, 2022 - cell.com
Type I and II interferons (IFNs) stimulate pro-inflammatory programs that are critical for
immune activation, but also induce immune-suppressive feedback circuits that impede …

Type I interferons as joint regulators of tumor growth and obesity

S Gessani, F Belardelli - Cancers, 2021 - mdpi.com
Simple Summary The escalating global epidemic of overweight and obesity is a major public
health and economic problem, as excess body weight represents a significant risk factor for …

Role of cellular metabolism in regulating type I interferon responses: Implications for tumour immunology and treatment

D Ahmed, E Cassol - Cancer Letters, 2017 - Elsevier
Type I interferons (IFN) are increasingly recognized for their role in regulating anti-tumour
immune responses. However, chronic activation of these pathways can result in …

IRF7 is a prognostic biomarker and associated with immune infiltration in stomach adenocarcinoma

L Guo, T Fang, Y Jiang, D Liu - International Journal of General …, 2021 - Taylor & Francis
Background Stomach adenocarcinoma (STAD) is one of the most prevalent malignances,
ranking fifth in incidence and third in mortality among all malignances. Interferon regulatory …

IRF2–INPP4B-mediated autophagy suppresses apoptosis in acute myeloid leukemia cells

F Zhang, J Li, J Zhu, L Liu, K Zhu, S Cheng, RD Lv… - Biological Research, 2019 - Springer
Background The present study aimed to investigate the underlying role of interferon-
regulatory factor 2 (IRF2)–inositol polyphosphate-4-phosphatase, type-II (INPP4B) axis in …

Upregulation of long noncoding RNA Lnc‐IRF2‐3 and Lnc‐ZNF667‐AS1 is associated with poor survival in B‐chronic lymphocytic leukemia

N El‐Khazragy, MA Esmaiel… - International Journal …, 2020 - Wiley Online Library
Abstract Background Lnc‐IRF2‐3 and Lnc‐ZNF667‐AS1 were recently studied as a positive
biomarker for many tumor cells. However, experimental studies found that they are …

Effect of interferon regulatory factor 2 on inflammatory response and oxidative stress in lipopolysaccharide‐induced acute kidney injury

T He, L Yang, D Wu - Drug Development Research, 2022 - Wiley Online Library
Interferon regulatory factor (IRF) 2 plays an important role in lipopolysaccharide (LPS)‐
induced acute kidney injury (AKI). In this study, we explored the effects of IRF2 on apoptosis …

Expression of interferon regulatory factor family and its prognostic value in acute myeloid leukemia

J Zeng, J Yao, Y Zhou, L Yu, L Zhang, C Wang… - Future …, 2023 - Taylor & Francis
Aim: To elucidate the clinicopathological and prognostic values of interferon regulatory
factor (IRF) family genes in acute myeloid leukemia (AML). Patients & methods: Differential …

[HTML][HTML] Identification of the prognostic value and clinical significance of interferon regulatory factors (IRFs) in colon adenocarcinoma

M Yuemaier, Z Zhou, Y Zhou, C Wu, F Li… - … Medical Journal of …, 2020 - ncbi.nlm.nih.gov
Background Colon adenocarcinoma (COAD) is one of the most common malignant tumors
and has high incidence and mortality rates. The interferon regulatory factor (IRF) family is …

[HTML][HTML] Transcriptome changes in colorectal cancer cells upon treatment with Avicequinone B

Y Ocampo, D Caro, D Rivera, J Piermattey… - Advanced …, 2020 - ncbi.nlm.nih.gov
Purpose: Naphtho [2, 3-b] furan-4, 9-dione (Avicequinone B), a natural naphthoquinone
isolated from the mangrove tree Avicennia alba, is recognized as a valuable synthetic …