Selective targeting of the TLR2/MyD88/NF-κB pathway reduces α-synuclein spreading in vitro and in vivo
Pathways to control the spreading of α-synuclein (α-syn) and associated neuropathology in
Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies …
Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies …
Stimuli-responsive In situ gelling system for nose-to-brain drug delivery
The diagnosis and treatment of neurological ailments always remain an utmost challenge for
research fraternity due to the presence of BBB. The intranasal route appeared as an …
research fraternity due to the presence of BBB. The intranasal route appeared as an …
Vibrational spectroscopy fingerprinting in medicine: from molecular to clinical practice
In the last two decades, Fourier Transform Infrared (FTIR) and Raman spectroscopies turn
out to be valuable tools, capable of providing fingerprint-type information on the composition …
out to be valuable tools, capable of providing fingerprint-type information on the composition …
Strategies for structural modification of small molecules to improve blood–brain barrier penetration: a recent perspective
B Xiong, Y Wang, Y Chen, S Xing, Q Liao… - Journal of Medicinal …, 2021 - ACS Publications
In the development of central nervous system (CNS) drugs, the blood–brain barrier (BBB)
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
restricts many drugs from entering the brain to exert therapeutic effects. Although many …
Global synergistic actions to improve brain health for human development
MO Owolabi, M Leonardi, C Bassetti… - Nature Reviews …, 2023 - nature.com
The global burden of neurological disorders is substantial and increasing, especially in low-
resource settings. The current increased global interest in brain health and its impact on …
resource settings. The current increased global interest in brain health and its impact on …
mtDNA-STING Axis Mediates Microglial Polarization via IRF3/NF-κB Signaling After Ischemic Stroke
L Kong, W Li, E Chang, W Wang, N Shen, X Xu… - Frontiers in …, 2022 - frontiersin.org
Neuroinflammation is initiated in response to ischemic stroke, and is usually characterized
by microglial activation and polarization. Stimulator of interferon genes (STING) has been …
by microglial activation and polarization. Stimulator of interferon genes (STING) has been …
[HTML][HTML] The effects of intermittent fasting on brain and cognitive function
The importance of diet and the gut-brain axis for brain health and cognitive function is
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …
increasingly acknowledged. Dietary interventions are tested for their potential to prevent …
Socioeconomic status and stroke incidence, prevalence, mortality, and worldwide burden: an ecological analysis from the Global Burden of Disease Study 2017
Background Socioeconomic status (SES) is associated with stroke incidence and mortality.
Distribution of stroke risk factors is changing worldwide; evidence on these trends is crucial …
Distribution of stroke risk factors is changing worldwide; evidence on these trends is crucial …
Epilepsy in older people
Globally, as populations age there will be challenges and opportunities to deliver optimal
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …
health care to senior citizens. Epilepsy, a condition characterised by spontaneous recurrent …
Ambient air pollution and the risk of ischaemic and haemorrhagic stroke
JI Verhoeven, Y Allach, ICH Vaartjes… - The Lancet Planetary …, 2021 - thelancet.com
Stroke is a leading cause of disability and the second most common cause of death
worldwide. Increasing evidence suggests that air pollution is an emerging risk factor for …
worldwide. Increasing evidence suggests that air pollution is an emerging risk factor for …