Drug conjugates, including antibody-drug conjugates, are a step toward realizing Paul
Ehrlich's idea from over 100 years ago of a “magic bullet” for cancer treatment. Through …

Purpose The m5C RNA methylation regulators are closely related to tumor proliferation,
occurrence, and metastasis. This study aimed to investigate the gene expression …

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer‑related deaths among
cancer patients. Genes correlated with the progression and prognosis of HCC are critically …

AIMS: Andrographolide, a principal diterpenoid lactone isolated from the traditional herbal
medicine Andrographis paniculata, has been reported to show anti-tumor activity. Since the …

Background and aim Cyclins have been reported to be overexpressed with poor prognosis
in several human cancers. However, limited numbers of studies evaluated the expressions …

Epigenetic silencing of tumor suppressor genes by promoter methylation plays vital roles in
the process of carcinogenesis. The purpose of this meta‐analysis was to determine whether …

Lycopene is the predominant and bioactive carotenoid present in the tomato (Solanum
lycopersicum), a widely appreciated healthful vegetable. In vivo, in vitro and clinical studies …

WYK431, a novel synthetic quinazoline derivative, showing potent inhibition of proliferation
activity against a broad spectrum of human cancer cell lines. We investigated the anticancer …

We have recently cloned a novel splice variant of cyclin D2 termed as cycD2SV. CycD2SV
overexpression in several immortalized cell lines led to formation of ubiquitinated protein …

Atypical cyclins have recently emerged as a new subfamily of cyclins characterized by
common structural features and interactor pattern. Interestingly, atypical cyclins are …