Mycotoxins' toxicological mechanisms involving humans, livestock and their associated health concerns: A review

CG Awuchi, EN Ondari, S Nwozo, GA Odongo… - Toxins, 2022 - mdpi.com
Mycotoxins are well established toxic metabolic entities produced when fungi invade
agricultural/farm produce, and this happens especially when the conditions are favourable …

Ochratoxin A: Toxicity, oxidative stress and metabolism

Y Tao, S Xie, F Xu, A Liu, Y Wang, D Chen… - Food and Chemical …, 2018 - Elsevier
Ochratoxin A (OTA) is a widespread mycotoxin commonly found as a corn contaminant. It
has been shown to be nephrotoxic, hepatotoxic, teratogenic and immunotoxic to several …

Ochratoxins in food and feed: Occurrence and its impact on human health and management strategies

P Kumar, DK Mahato, B Sharma, R Borah, S Haque… - Toxicon, 2020 - Elsevier
Ochratoxins (OTs) are a group of mycotoxins produced by Aspergillus and Penicillium spp.
which are ubiquitous. They infect the crops during pre-and post-harvest conditions and …

Comparative ochratoxin toxicity: A review of the available data

AH Heussner, LEH Bingle - Toxins, 2015 - mdpi.com
Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA),
the most prominent member of this toxin family, was first described by van der Merwe et al. in …

A review on mycotoxins in food and feed: Malaysia case study

L Afsah‐Hejri, S Jinap, P Hajeb, S Radu… - … Reviews in food …, 2013 - Wiley Online Library
Fungi are distributed worldwide and can be found in various foods and feedstuffs from
almost every part of the world. Mycotoxins are secondary metabolites produced by some …

Network pharmacology of cancer: From understanding of complex interactomes to the design of multi-target specific therapeutics from nature

P Poornima, JD Kumar, Q Zhao, M Blunder… - Pharmacological …, 2016 - Elsevier
Despite massive investments in drug research and development, the significant decline in
the number of new drugs approved or translated to clinical use raises the question, whether …

Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach

LG Hernández, H van Steeg, M Luijten… - … Research/Reviews in …, 2009 - Elsevier
It is well established that cancer is a multi-step process which involves initiation, promotion
and progression. Chemical carcinogens can alter any of these processes to induce their …

Effects of different mycotoxins on humans, cell genome and their involvement in cancer

MA Ahmed Adam, YM Tabana… - Oncology …, 2017 - spandidos-publications.com
The chemical nature of most of the mycotoxins makes them highly liposoluble compounds
that can be absorbed from the site of exposure such as from the gastrointestinal and …

Toxin degradation by rumen microorganisms: a review

ZH Loh, D Ouwerkerk, AV Klieve, NL Hungerford… - Toxins, 2020 - mdpi.com
Animal feeds may contain exogenous compounds that can induce toxicity when ruminants
ingest them. These toxins are secondary metabolites originating from various sources …

Environmental toxicants, epigenetics, and cancer

IP Pogribny, I Rusyn - Epigenetic Alterations in Oncogenesis, 2012 - Springer
Tumorigenesis, a complex and multifactorial progressive process of transformation of normal
cells into malignant cells, is characterized by the accumulation of multiple cancer-specific …