There are a number of effective but highly toxic drugs that exhibit a narrow therapeutic index
and marked interpatient pharmacokinetic variability. Individualized therapy with such drugs …

The use of medications is common in elderly persons, and this population has the highest
risk of medication-related problems. Elderly persons are more susceptible to the effects of …

We report the synthesis, characterization, and photophysical and electrochemical properties
of thirty luminescent cyclometalated iridium (III) diimine complexes [Ir (NC) 2 (NN)](PF6)(HN …

Digitalis glycosides exert a positive inotropic effect, ie an increase in myocardial contractility
associated with a prolongation of relaxation period, and glycosides lower the heart rate …

Aberrant activation of the hypoxia inducible factor (HIF) pathway causing overexpression of
angiogenic genes, like vascular endothelial growth factor (VEGF), is one of the underlying …

Results: For hospital mortality, independent predic-tors were urgent surgery (Risk Ratio
10.2, 95% CI 2.5-42.0, p= 0.001); age over 80 (RR 4.5, CI 1.3-14.9; p= 0.015); need for …

Inotropic agents are drugs which increase the stroke work of the heart at a given pre-load
and after-load. All of these agents work through a final common pathway involving the …

Although digitalis has been used since the last century, it seems to be in the process of
being progressively abandoned. However, digoxin has demonstrated a large positive …

Heart failure, accompanied by structural or functional changes because of failure to deliver
sufficient oxygen to meet the metabolic needs of the tissues, is a complex clinical syndrome …

The existing regulatory framework for research is increasingly attacked for its “one-size-fits-
all” approach. Many stakeholders contend that existing regulations formulate the same …