[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective
SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …
essential physiological process for the growth of cells, tissue repair, wound healing, and …
[HTML][HTML] Reassessing vascular endothelial growth factor (VEGF) in anti-angiogenic cancer therapy
TC Elebiyo, D Rotimi, IO Evbuomwan… - Cancer Treatment and …, 2022 - Elsevier
Vascularization is fundamental to the growth and spread of tumor cells to distant sites. As a
consequence, angiogenesis, the sprouting of new blood vessels from existing ones, is a …
consequence, angiogenesis, the sprouting of new blood vessels from existing ones, is a …
Design, synthesis, docking, DFT, MD simulation studies of a new nicotinamide-based derivative: in vitro anticancer and VEGFR-2 inhibitory effects
A nicotinamide-based derivative was designed as an antiproliferative VEGFR-2 inhibitor
with the key pharmacophoric features needed to interact with the VEGFR-2 catalytic pocket …
with the key pharmacophoric features needed to interact with the VEGFR-2 catalytic pocket …
New quinoxaline-2 (1 H)-ones as potential VEGFR-2 inhibitors: Design, synthesis, molecular docking, ADMET profile and anti-proliferative evaluations
Eleven new quinoxaline derivatives were designed and synthesized as modified VEGFR-2
inhibitors of our previous work. The synthesized compounds were tested against three …
inhibitors of our previous work. The synthesized compounds were tested against three …
The Assessment of Anticancer and VEGFR-2 Inhibitory Activities of a New 1H-Indole Derivative: In Silico and In Vitro Approaches
Corresponding to the reported features of anti-VEGFR-2-approved compounds, a new 1 H-
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
indole derivative (compound 7) was designed. The inhibitory potential of the designed …
Discovery of new anticancer thiourea-azetidine hybrids: Design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity …
DR Parmar, JY Soni, R Guduru, RH Rayani… - Bioorganic …, 2021 - Elsevier
With the aim to discover potent and novel antitumor agents, a series of thiourea compounds
bearing 3-(4-methoxyphenyl) azetidine moiety were designed according to the essential …
bearing 3-(4-methoxyphenyl) azetidine moiety were designed according to the essential …
New quinoxaline derivatives as VEGFR-2 inhibitors with anticancer and apoptotic activity: Design, molecular modeling, and synthesis
Abstract New series of [1, 2, 4] triazolo [4, 3-a] quinoxalin-4 (5H)-one and [1, 2, 4] triazolo [4,
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
3-a] quinoxaline derivatives have been designed, synthesized, and biologically assessed for …
New bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives as VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, in silico studies, and anticancer …
A new series of bis ([1, 2, 4] triazolo)[4, 3-a: 3′, 4′-c] quinoxaline derivatives were
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …
designed and synthesized to have the main essential pharmacophoric features of VEGFR-2 …
Discovery of new quinoxaline-2 (1H)-one-based anticancer agents targeting VEGFR-2 as inhibitors: Design, synthesis, and anti-proliferative evaluation
VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …
Modified benzoxazole-based VEGFR-2 inhibitors and apoptosis inducers: Design, synthesis, and anti-proliferative evaluation
This work is one of our efforts to discover potent anticancer agents. We modified the most
promising derivative of our previous work concerned with the development of VEGFR-2 …
promising derivative of our previous work concerned with the development of VEGFR-2 …