Cancer drug resistance continues to be a major impediment in medical oncology. Clinically,
resistance can arise prior to or as a result of cancer therapy. In this review, we discuss …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

Although circular RNAs (circRNA) are known to modulate tumor initiation and progression,
their role in hepatocellular carcinoma (HCC) metastasis remains poorly understood. Here …

As more clinically relevant cancer genes are identified, comprehensive diagnostic
approaches are needed to match patients to therapies, raising the challenge of optimization …

Abstract The International Cancer Genome Consortium (ICGC) was launched to coordinate
large-scale cancer genome studies in tumors from 50 different cancer types and/or subtypes …

Abstract BACKGROUND. The American Cancer Society, the Centers for Disease Control
and Prevention (CDC), the National Cancer Institute (NCI), and the North American …

Recent advances in genome technologies and the ensuing outpouring of genomic
information related to cancer have accelerated the convergence of discovery science and …

Next-generation sequencing technologies have greatly expanded our understanding of
cancer genetics. Antisense technology is an attractive platform with the potential to translate …

An enhanced understanding of the molecular pathology of disease gained from genomic
studies is facilitating the development of treatments that target discrete molecular subclasses …

Abstract Background The American Cancer Society, the Centers for Disease Control and
Prevention (CDC), the National Cancer Institute (NCI), and the North American Association …