Pulmonary fibrosis: from pathogenesis to clinical decision-making

T Koudstaal, M Funke-Chambour, M Kreuter… - Trends in molecular …, 2023 - cell.com
Pulmonary fibrosis (PF) encompasses a spectrum of chronic lung diseases that
progressively impact the interstitium, resulting in compromised gas exchange …

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

PJ Wolters, TS Blackwell, O Eickelberg… - The Lancet …, 2018 - thelancet.com
Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible, and typically fatal lung
disease characterised by subpleural fibrosis, subepithelial fibroblast foci, and microscopic …

[HTML][HTML] Dysregulated lung commensal bacteria drive interleukin-17B production to promote pulmonary fibrosis through their outer membrane vesicles

D Yang, X Chen, J Wang, Q Lou, Y Lou, L Li, H Wang… - Immunity, 2019 - cell.com
Idiopathic pulmonary fibrosis (IPF) is a severe form of lung fibrosis with a high mortality rate.
However, the etiology of IPF remains unknown. Here, we report that alterations in lung …

[HTML][HTML] Interstitial lung disease in connective tissue disease: a common lesion with heterogeneous mechanisms and treatment considerations

T Shao, X Shi, S Yang, W Zhang, X Li, J Shu… - Frontiers in …, 2021 - frontiersin.org
Connective tissue disease (CTD) related interstitial lung disease (CTD-ILD) is one of the
leading causes of morbidity and mortality of CTD. Clinically, CTD-ILD is highly heterogenous …

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a …

A Dressen, AR Abbas, C Cabanski… - The Lancet …, 2018 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) risk has a strong genetic component. Studies
have implicated variations at several loci, including TERT, surfactant genes, and a single …

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

AE John, C Joseph, G Jenkins… - Immunological reviews, 2021 - Wiley Online Library
The COVID‐19 pandemic rapidly spread around the world following the first reports in
Wuhan City, China in late 2019. The disease, caused by the novel SARS‐CoV‐2 virus, is …

[HTML][HTML] Molecular biomarkers in idiopathic pulmonary fibrosis: state of the art and future directions

A Stainer, P Faverio, S Busnelli, M Catalano… - International Journal of …, 2021 - mdpi.com
Idiopathic pulmonary fibrosis (IPF), the most lethal form of interstitial pneumonia of unknown
cause, is associated with a specific radiological and histopathological pattern (the so-called …

[HTML][HTML] The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis

S Bolourani, M Brenner, P Wang - Journal of Molecular Medicine, 2021 - Springer
Pulmonary fibrosis is a chronic debilitating condition characterized by progressive
deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in …

[HTML][HTML] Lung organoids, useful tools for investigating epithelial repair after lung injury

J Kong, S Wen, W Cao, P Yue, X Xu, Y Zhang… - Stem cell research & …, 2021 - Springer
Organoids are derived from stem cells or organ-specific progenitors. They display structures
and functions consistent with organs in vivo. Multiple types of organoids, including lung …

[HTML][HTML] FBW7 mediates senescence and pulmonary fibrosis through telomere uncapping

L Wang, R Chen, G Li, Z Wang, J Liu, Y Liang, JP Liu - Cell Metabolism, 2020 - cell.com
Tissue stem cells undergo premature senescence under stress, promoting age-related
diseases; however, the associated mechanisms remain unclear. Here, we report that in …