Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

Depression is a common mental illness, affecting more than 300 million people worldwide.
Decades of investigation have yielded symptomatic therapies for this disabling condition but …

Growth factors (GFs) are soluble proteins secreted by cells that have the ability to regulate a
variety of cellular processes and tissue regeneration. However, their translation into clinical …

Fractures are the most common large-organ, traumatic injuries to humans. The repair of
bone fractures is a postnatal regenerative process that recapitulates many of the ontological …

Enabling angiogenesis is critical for the success of tissue repair therapies and the fate of
tissue-engineered constructs. Although many biochemical signaling molecules have been …

Aim To review the knowledge on the mechanisms controlling membrane–host interactions in
guided bone regeneration (GBR) and investigate the possible role of GBR membranes as …

Fibroblast growth factor (FGF) signaling pathways are essential regulators of vertebrate
skeletal development. FGF signaling regulates development of the limb bud and formation of …

Growth factors are very promising molecules to enhance bone regeneration. However, their
translation to clinical use has been seriously limited, facing issues related to safety and cost …

Presently, there is a high paucity of bone grafts in the United States and worldwide.
Regenerating bone is of prime concern due to the current demand of bone grafts and the …

Bone regeneration represents a complex process, of which basic biologic principles have
been evolutionarily conserved over a broad range of different species. Bone represents one …