Harnessing genomics to fast-track genetic improvement in aquaculture

RD Houston, TP Bean, DJ Macqueen… - Nature Reviews …, 2020 - nature.com
Aquaculture is the fastest-growing farmed food sector and will soon become the primary
source of fish and shellfish for human diets. In contrast to crop and livestock production …

[PDF][PDF] Enhancing genetic gain through genomic selection: from livestock to plants

Y Xu, X Liu, J Fu, H Wang, J Wang, C Huang… - Plant …, 2020 - cell.com
Although long-term genetic gain has been achieved through increasing use of modern
breeding methods and technologies, the rate of genetic gain needs to be accelerated to …

Bringing the animal QTLdb and CorrDB into the future: meeting new challenges and providing updated services

ZL Hu, CA Park, JM Reecy - Nucleic acids research, 2022 - academic.oup.com
Abstract The Animal QTLdb (https://www. animalgenome. org/QTLdb) and CorrDB
(https://www. animalgenome. org/CorrDB) are unique resources for livestock animal …

[HTML][HTML] ABO genotype alters the gut microbiota by regulating GalNAc levels in pigs

H Yang, J Wu, X Huang, Y Zhou, Y Zhang, M Liu, Q Liu… - Nature, 2022 - nature.com
The composition of the intestinal microbiome varies considerably between individuals and is
correlated with health. Understanding the extent to which, and how, host genetics …

Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle

L Fang, W Cai, S Liu, O Canela-Xandri, Y Gao… - Genome …, 2020 - genome.cshlp.org
By uniformly analyzing 723 RNA-seq data from 91 tissues and cell types, we built a
comprehensive gene atlas and studied tissue specificity of genes in cattle. We demonstrated …

[HTML][HTML] Genome-wide fine-mapping identifies pleiotropic and functional variants that predict many traits across global cattle populations

R Xiang, IM MacLeod, HD Daetwyler, G de Jong… - Nature …, 2021 - nature.com
The difficulty in finding causative mutations has hampered their use in genomic prediction.
Here, we present a methodology to fine-map potentially causal variants genome-wide by …

[HTML][HTML] From FAANG to fork: application of highly annotated genomes to improve farmed animal production

EL Clark, AL Archibald, HD Daetwyler, MAM Groenen… - Genome Biology, 2020 - Springer
The Food and Agriculture Organisation of the United Nations (FAO) reports that by the year
2050 the global human population is likely to reach 9.7 billion, rising to 11.2 billion by 2100 …

[PDF][PDF] Current status of genomic evaluation

I Misztal, D Lourenco, A Legarra - Journal of Animal Science, 2020 - academic.oup.com
Early application of genomic selection relied on SNP estimation with phenotypes or de-
regressed proofs (DRP). Chips of 50k SNP seemed sufficient for an accurate estimation of …

HIBLUP: an integration of statistical models on the BLUP framework for efficient genetic evaluation using big genomic data

L Yin, H Zhang, Z Tang, D Yin, Y Fu… - Nucleic Acids …, 2023 - academic.oup.com
Human diseases and agricultural traits can be predicted by modeling a genetic random
polygenic effect in linear mixed models. To estimate variance components and predict …

A framework for microbiome science in public health

JE Wilkinson, EA Franzosa, C Everett, C Li, FB Hu… - Nature medicine, 2021 - nature.com
Human microbiome science has advanced rapidly and reached a scale at which basic
biology, clinical translation and population health are increasingly integrated. It is thus now …