[HTML][HTML] Cannabidiol for the treatment of brain disorders: therapeutic potential and routes of administration

GTY Yau, W Tai, JC Arnold, HK Chan… - Pharmaceutical …, 2023 - Springer
The use of cannabidiol (CBD) for treating brain disorders has gained increasing interest.
While the mechanism of action of CBD in these conditions is still under investigation, CBD …

Nanoformulations as a strategy to overcome the delivery limitations of cannabinoids

TS Reddy, R Zomer, N Mantri - Phytotherapy Research, 2023 - Wiley Online Library
Medical cannabis has received significant interest in recent years due to its promising
benefits in the management of pain, anxiety, depression and neurological and movement …

[HTML][HTML] Current challenges and opportunities for improved cannabidiol solubility

KR Hossain, A Alghalayini, SM Valenzuela - International Journal of …, 2023 - mdpi.com
Cannabidiol (CBD), derived from the cannabis plant, has gained significant attention due to
its potential therapeutic benefits. However, one of the challenges associated with CBD …

Therapeutic targeting of the tumor microenvironments with cannabinoids and their analogs: Update on clinical trials

A Sheik, MR Farani, E Kim, S Kim, VK Gupta… - Environmental …, 2023 - Elsevier
Cancer is a major global public health concern that affects both industrialized and
developing nations. Current cancer chemotherapeutic options are limited by side effects, but …

The dose-dependent effect of a stabilized cannabidiol nanoemulsion on ocular surface inflammation and intraocular pressure

L Rebibo, M Frušić-Zlotkin, R Ofri, T Nassar… - International Journal of …, 2022 - Elsevier
Cannabidiol (CBD) is a phytocannabinoid that has a great clinical therapeutic potential. Few
studies have been published on its efficacy in ocular inflammations while its impact on …

An update of nano-based drug delivery systems for cannabinoids: Biopharmaceutical aspects & therapeutic applications

ERL Rebelatto, GS Rauber, T Caon - International Journal of …, 2023 - Elsevier
Nanotechnology has been widely used to improve stability, efficacy, release control and
biopharmaceutical aspects of natural and synthetic cannabinoids. In this review, the main …

[HTML][HTML] Development and characterization of nanostructured lipid carriers for cannabidiol delivery

R Vardanega, FL Lüdtke, L Loureiro, RFS Gonçalves… - Food Chemistry, 2024 - Elsevier
This study evaluated the physicochemical characteristics of nanostructured lipid carriers
(NLCs) as a potential vehicle for cannabidiol (CBD), a lipophilic molecule with great …

[HTML][HTML] Strategies to improve cannabidiol bioavailability and drug delivery

SE O'Sullivan, SS Jensen, AR Kolli, GN Nikolajsen… - Pharmaceuticals, 2024 - mdpi.com
The poor physicochemical properties of cannabidiol (CBD) hamper its clinical development.
The aim of this review was to examine the literature to identify novel oral products and …

Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development

N Fine-Shamir, A Dahan - Expert Opinion on Drug Delivery, 2024 - Taylor & Francis
Introduction Tackling low water solubility of drug candidates is a major challenge in today's
pharmaceutics/biopharmaceutics, especially by means of modern solubility-enabling …

[HTML][HTML] Amphiphilic block copolymers bearing fatty acid derivatives as vehicles for THC in the development of analgesic oral formulations

JD Porras, Y Román, J Palacio… - Reactive and Functional …, 2024 - Elsevier
Cannabis-based therapeutics have gained increasing attention for their potential health
benefits; however, the efficient administration of hydrophobic constituents such as Δ9 …