Factors leading to high morbidity and mortality of COVID‐19 in patients with type 2 diabetes
Abstract Coronavirus disease 2019 (COVID‐19) is a recent pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus. Diabetes …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel coronavirus. Diabetes …
[HTML][HTML] Mitochondria and metabolic transitions in cardiomyocytes: lessons from development for stem cell-derived cardiomyocytes
JC Garbern, RT Lee - Stem Cell Research & Therapy, 2021 - Springer
Current methods to differentiate cardiomyocytes from human pluripotent stem cells (PSCs)
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …
inadequately recapitulate complete development and result in PSC-derived cardiomyocytes …
[HTML][HTML] Metformin and risk of mortality in patients hospitalised with COVID-19: a retrospective cohort analysis
Background Type 2 diabetes and obesity, as states of chronic inflammation, are risk factors
for severe COVID-19. Metformin has cytokine-reducing and sex-specific immunomodulatory …
for severe COVID-19. Metformin has cytokine-reducing and sex-specific immunomodulatory …
[HTML][HTML] Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice
F Xue, J Cheng, Y Liu, C Cheng, M Zhang… - … and Targeted Therapy, 2022 - nature.com
Abstract Angiotensin-converting enzyme 2 (ACE2) has proven beneficial in attenuating
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …
diabetic cardiomyopathy (DCM) but has been found to be a substrate of a disintegrin and …
[HTML][HTML] Metformin in COVID-19: a possible role beyond diabetes
It is a lesser-known fact that metformin was originally introduced as an anti-influenza drug
and that glucose-lowering was only one of its side effects [1]. The many pleiotropic effects of …
and that glucose-lowering was only one of its side effects [1]. The many pleiotropic effects of …
[HTML][HTML] Observational study of metformin and risk of mortality in patients hospitalized with Covid-19
Objective: We sought to identify whether metformin reduced mortality from Covid19 and if
sex specific interactions exist. Design: Retrospective review of de-identified claims from …
sex specific interactions exist. Design: Retrospective review of de-identified claims from …
Daily and seasonal mitochondrial protection: Unraveling common possible mechanisms involving vitamin D and melatonin
From an evolutionary point of view, vitamin D and melatonin appeared very early and share
functions related to defense mechanisms. In the current clinical setting, vitamin D is …
functions related to defense mechanisms. In the current clinical setting, vitamin D is …
[HTML][HTML] Metformin and Covid-19: focused review of mechanisms and current literature suggesting benefit
S Ibrahim, JR Lowe, CT Bramante, S Shah… - Frontiers in …, 2021 - frontiersin.org
Metformin is the first-line medication for type 2 diabetes, but it also has a long history of
improved outcomes in infectious diseases, such as influenza, hepatitis C, and in-vitro assays …
improved outcomes in infectious diseases, such as influenza, hepatitis C, and in-vitro assays …
[HTML][HTML] HRAS germline mutations impair LKB1/AMPK signaling and mitochondrial homeostasis in Costello syndrome models
Germline mutations that activate genes in the canonical RAS/MAPK signaling pathway are
responsible for rare human developmental disorders known as RASopathies. Here, we …
responsible for rare human developmental disorders known as RASopathies. Here, we …
[HTML][HTML] Adverse effects of metformin from diabetes to COVID-19, cancer, neurodegenerative diseases, and aging: is VDAC1 a common target?
V Shoshan-Barmatz, U Anand, E Nahon-Crystal… - Frontiers in …, 2021 - frontiersin.org
Metformin has been used for treating diabetes mellitus since the late 1950s. In addition to its
antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range …
antihyperglycemic activity, it was shown to be a potential drug candidate for treating a range …