Compounds targeted for the treatment of Alzheimer's Disease (AD) have consistently failed
in clinical trials despite evidence for target engagement and pharmacodynamic activity. This …

Pharmacological research has always focused on developing new therapeutic strategies
capable of modifying a disease's natural history and improving patients' quality of life …

Sixty years after its discovery, the lysosome is no longer considered as cell's waste bin but
as an organelle playing a central role in cell metabolism. Besides its well known association …

Researchers are paying more and more attention to aging, especially skin aging. Therefore,
it is urgent to find an effective way to inhibit aging. Here, we report a small chemical …

Abstract The Gene Ontology (GO) is widely recognised as the gold standard bioinformatics
resource for summarizing functional knowledge of gene products in a consistent and …

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and autophagy
that plays a key role in the regulation of cellular clearance pathways. TFEB is regulated via a …

Exposure of the yeast Saccharomyces cerevisiae to environmental stress can influence cell
growth, physiology and differentiation, and thus result in a cell's adaptive response. During …

Sažetak Parkinson's disease (PD) is a progressive neurodegenerative disease. Levodopa in
combination with amantadine has a demonstrated efficacy in motility impairment. An …

The neuronal ceroid lipofuscinoses (NCLs), colloquially referred to as Batten disease (BD),
encompass a heterogenous group of neurodegenerative lysosomal storage disorders …

It is surely beyond doubt that every organ of the human being is important, but the brain, the
main command center of all organs, has a much greater importance. Any problems that may …