Vascular endothelial cells and innate immunity

Y Shao, J Saredy, WY Yang, Y Sun, Y Lu… - … , and vascular biology, 2020 - Am Heart Assoc
In addition to the roles of endothelial cells (ECs) in physiological processes, ECs actively
participate in both innate and adaptive immune responses. We previously reported that, in …

[HTML][HTML] An evolving new paradigm: endothelial cells–conditional innate immune cells

J Mai, A Virtue, J Shen, H Wang, XF Yang - Journal of hematology & …, 2013 - Springer
Endothelial cells (ECs) are a heterogeneous population that fulfills many physiological
processes. ECs also actively participate in both innate and adaptive immune responses …

Angiotensin II AT1 receptor blockers as treatments for inflammatory brain disorders

JM Saavedra - Clinical science, 2012 - portlandpress.com
The effects of brain AngII (angiotensin II) depend on AT1 receptor (AngII type 1 receptor)
stimulation and include regulation of cerebrovascular flow, autonomic and hormonal …

The vascular endothelium: A regulator of arterial tone and interface for the immune system

R Khaddaj Mallat, C Mathew John… - Critical reviews in …, 2017 - Taylor & Francis
As the primary interface between the blood and various tissues of the body, the vascular
endothelium exhibits a diverse range of roles and activities, all of which contribute to the …

PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax–caspase9–caspase3 pathway

CY Wu, ZH Tang, L Jiang, XF Li, ZS Jiang… - Molecular and cellular …, 2012 - Springer
This paper investigated the effects of ox-LDL on PCSK9, and the molecular mechanisms of
PCSK9 siRNA-inhibited apoptosis induced by ox-LDL in human umbilical vein endothelial …

[HTML][HTML] Role of vascular smooth muscle cell in the inflammation of atherosclerosis

S Lim, S Park - BMB reports, 2014 - ncbi.nlm.nih.gov
Atherosclerosis is a pathologic process occurring within the artery, in which many cell types,
including T cell, macrophages, endothelial cells, and smooth muscle cells, interact, and …

Anthocyanins and their physiologically relevant metabolites alter the expression of IL‐6 and VCAM‐1 in CD40L and oxidized LDL challenged vascular endothelial …

HP Amin, C Czank, S Raheem, Q Zhang… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope In vitro and in vivo studies suggest that dietary anthocyanins modulate cardiovascular
disease risk; however, given anthocyanins extensive metabolism, it is likely that their …

Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles

A Goette, A Bukowska, D Dobrev… - European heart …, 2009 - academic.oup.com
Aims Patients with paroxysmal atrial fibrillation (AF) often present with typical angina
pectoris and mildly elevated levels of cardiac troponin (non ST-segment elevation …

Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis

L Ma, J Zhong, Z Zhao, Z Luo, S Ma, J Sun… - Cardiovascular …, 2011 - academic.oup.com
Aims Activation of transient receptor potential vanilloid type-1 (TRPV1) channels may affect
lipid storage and the cellular inflammatory response. Now, we tested the hypothesis that …

Dual signaling evoked by oxidized LDLs in vascular cells

A Nègre-Salvayre, N Augé, C Camaré… - Free Radical Biology …, 2017 - Elsevier
The oxidative theory of atherosclerosis relies on the modification of low density lipoproteins
(LDLs) in the vascular wall by reactive oxygen species. Modified LDLs, such as oxidized …