Physiology, signaling, and pharmacology of galanin peptides and receptors: three decades of emerging diversity
R Lang, AL Gundlach, FE Holmes, SA Hobson… - Pharmacological …, 2015 - ASPET
Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies
D Reichart, EL Lindberg, H Maatz, AMA Miranda… - Science, 2022 - science.org
Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic
cardiomyopathy (ACM) convey high risks for the development of heart failure through …
cardiomyopathy (ACM) convey high risks for the development of heart failure through …
Galanin receptors and ligands
KEB Webling, J Runesson, T Bartfai… - Frontiers in …, 2012 - frontiersin.org
The neuropeptide galanin was first discovered 30 years ago. Today, the galanin family
consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide …
consists of galanin, galanin-like peptide (GALP), galanin-message associated peptide …
MicroRNA profiles in hippocampal granule cells and plasma of rats with pilocarpine-induced epilepsy–comparison with human epileptic samples
The identification of biomarkers of the transformation of normal to epileptic tissue would help
to stratify patients at risk of epilepsy following brain injury and inform new treatment …
to stratify patients at risk of epilepsy following brain injury and inform new treatment …
Neuropeptides in epilepsy
S Kovac, MC Walker - Neuropeptides, 2013 - Elsevier
Neuropeptides play an important role in modulating seizures and epilepsy. Unlike
neurotransmitters which operate on a millisecond time-scale, neuropeptides have longer …
neurotransmitters which operate on a millisecond time-scale, neuropeptides have longer …
Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice
A Reyes-Alcaraz, YN Lee, GH Son, NH Kim, DK Kim… - Scientific reports, 2016 - nature.com
The novel neuropeptide spexin (SPX) was discovered to activate galanin receptor 2
(GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to …
(GALR2) and 3 (GALR3) but not galanin receptor 1 (GALR1). Although GALR2 is known to …
G protein-coupled receptors in acquired epilepsy: Druggability and translatability
As the largest family of membrane proteins in the human genome, G protein-coupled
receptors (GPCRs) constitute the targets of more than one-third of all modern medicinal …
receptors (GPCRs) constitute the targets of more than one-third of all modern medicinal …
Strain differences in seizure-induced cell death following pilocarpine-induced status epilepticus
PE Schauwecker - Neurobiology of disease, 2012 - Elsevier
Mouse strains differ from one another in their susceptibility to seizure-induced excitotoxic
cell death. Previously, we have demonstrated that mature inbred strains of mice show …
cell death. Previously, we have demonstrated that mature inbred strains of mice show …
Repeated low-dose kainate administration in C57BL/6J mice produces temporal lobe epilepsy pathology but infrequent spontaneous seizures
AD Umpierre, IV Bennett, LD Nebeker, TG Newell… - Experimental …, 2016 - Elsevier
More efficient or translationally relevant approaches are needed to model acquired temporal
lobe epilepsy (TLE) in genetically tractable mice. The high costs associated with breeding …
lobe epilepsy (TLE) in genetically tractable mice. The high costs associated with breeding …
[HTML][HTML] Activation of galanin receptor 1 with M617 attenuates neuronal apoptosis via ERK/GSK-3β/TIP60 pathway after subarachnoid hemorrhage in rats
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular disease. Neuronal
apoptosis plays an important pathological role in early brain injury after SAH. Galanin …
apoptosis plays an important pathological role in early brain injury after SAH. Galanin …