Proteins are nature's primary building blocks for the construction of sophisticated molecular
machines and dynamic materials, ranging from protein complexes such as photosystem II …

Nature endows life with a wide variety of sophisticated, synergistic, and highly functional
protein assemblies. Following Nature's inspiration to assemble protein building blocks into …

Nature provides many examples of self-and co-assembling protein-based molecular
machines, including icosahedral protein cages that serve as scaffolds, enzymes, and …

The self-assembly of proteins into highly ordered nanoscale architectures is a hallmark of
biological systems. The sophisticated functions of these molecular machines have inspired …

We describe a general computational method for designing proteins that self-assemble to a
desired symmetric architecture. Protein building blocks are docked together symmetrically to …

Interactions between proteins are orchestrated in a precise and time-dependent manner,
underlying cellular function. The binding affinity, defined as the strength of these …

The use of monoclonal antibodies as therapeutics requires optimizing several of their key
attributes. These include binding affinity and specificity, folding stability, solubility …

Asymmetric multiprotein complexes that undergo subunit exchange play central roles in
biology but present a challenge for design because the components must not only contain …

Self-assembling cyclic protein homo-oligomers play important roles in biology, and the
ability to generate custom homo-oligomeric structures could enable new approaches to …

The accurate design of new protein–protein interactions is a longstanding goal of
computational protein design. However, most computationally designed interfaces fail to …