Free radicals are often described as chemical compounds characterized by unpaired
electrons in their outer orbital rendering them highly reactive species. In mammalians …

The activation of macrophage respiratory burst in response to infection with Trypanosoma
cruzi inflicts oxidative damage to the host's tissues. For decades, the role of reactive oxygen …

The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public
health problem throughout Latin America. Current therapeutic options are characterised by …

Chagas disease is a neglected tropical disease, which affects an estimate of 6‐7 million
people worldwide. Chagas disease is caused by Trypanosoma cruzi, which is a eukaryotic …

Flavonoids have demonstrated in vivo and in vitro leishmanicidal, trypanocidal, antioxidant,
and prooxidant properties. The chemotherapy of trypanosomiasis and leishmaniasis lacks …

Trypanosoma cruzi is the etiologic agent of Chagas' disease. Infected cells with T. cruzi
activate several responses that promote unbalance of reactive oxygen species (ROS) that …

Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the
causative agent of Chagas disease. However, for reasons that are unknown, treatment …

The toxicity of oxygen and nitrogen reactive species appears to be merely the tip of the
iceberg in the world of redox homeostasis. Now, oxidative stress can be seen as a two-sided …

Although the exact etiology of Chagas disease is not completely elucidated, thymic atrophy
and oxidative stress are believed to be important contributors to the pathogenesis during …

Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and affects 6–8
million people worldwide, mainly from developing countries. The treatment is limited to two …