Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

We summarize the biological impact of leptin signaling as well as the molecular and cellular
characteristics of leptin action. Our focus is principally in the central nervous system and we …

Elevations in branched-chain amino acids (BCAAs) in human obesity were first reported in
the 1960s. Such reports are of interest because of the emerging role of BCAAs as potential …

Adiponectin, made exclusively by adipocytes, is a 30-kDa secretory protein assembled
posttranslationally into low-molecular weight, middle-molecular weight, and high-molecular …

This review summarizes recent advances in our understanding of the pre-and
posttranscriptional mechanisms that regulate leptin production and secretion in adipocytes …

Increased adipocyte size is hypothesized to signal the recruitment of adipose progenitor
cells (APCs) to expand tissue storage capacity. To investigate depot and sex differences in …

Leptin and its receptor are widely distributed in several tissues, mainly in white adipose
tissue. The serum leptin is highly correlated with body mass index in rodents and humans …

Serum leptin levels are upregulated in proportion to body fat and also increase over the
short term in response to meals or insulin. To understand the mechanisms involved, we …

Based on recent evidence that fatty acid synthase and endogenously produced fatty acid
derivatives are required for adipogenesis in 3T3-L1 adipocytes, we conducted a small …

The mouse growth hormone receptor/growth hormone-binding protein (GHR/BP) gene
produces several distinct mRNA forms through alternative splicing, including mRNAs …