Stunted growth is a major complication of chronic inflammation and recurrent infections in
children. Systemic juvenile rheumatoid arthritis is a chronic inflammatory disorder …

It is becoming well accepted that products of the immune system (cytokines) can signal the
brain that infection has occurred. This cytokine-to-brain communication can result in marked …

Recent studies from this laboratory have provided some evidence that major depression, in
particular melancholia, may be accompanied by an immune response. The present study …

Systemic and localized inflammation elicit a number of host responses which include fever,
cachexia, hypoglycemia, and major changes in the concentration of liver plasma proteins …

Vaccinia virus gene B15R is shown to encode an abundant, secretory glycoproteln that
functions as a soluble interleukln-1 (IL-l) receptor. This IL-1 receptor has novel specificity …

Treating the septic shock syndrome with antibodies that block onlyendotoxin has its
limitations. Othertargetsfor treatingseptic shockinclude neutralizing antibodies to the …

We used gene targeting in embryonic stem cells to introduce an IL-lf3 null allele in mice. The
IL-lft-deficient mice develop normally and are apparently healthy and fertile. The IL-18 null …

The systemic inflammatory response syndrome (SIRS) is an acute illness characterized by
generalized activation of the endothelium. The most severe form of the syndrome is found in …

Publisher Summary This chapter reviews the role of cytokines in the pathogenesis of sepsis.
The various models for sepsis are also discussed, including the human models and animal …

Intranasal inoculation of type 5 adenovirus (Ad5) produced pneumonia in mice even though
the virus did not replicate. To induce the pneumonia, however, a large viral infectious dose …