[HTML][HTML] Targeting the synapse in Alzheimer's disease
J Jackson, E Jambrina, J Li, H Marston… - Frontiers in …, 2019 - frontiersin.org
Dynamic gain and loss of synapses is fundamental to healthy brain function. While
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …
Alzheimer's Disease (AD) treatment strategies have largely focussed on beta-amyloid and …
Hippocampal neurogenesis: learning to remember
O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
Ascending monoaminergic systems alterations in Alzheimer's disease. Translating basic science into clinical care
Extensive neuropathological studies have established a compelling link between
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …
abnormalities in structure and function of subcortical monoaminergic (MA-ergic) systems …
Microglial dysfunction connects depression and Alzheimer's disease
Alzheimer's disease (AD) and major depressive disorder (MDD) are highly prevalent
neuropsychiatric conditions with intriguing epidemiological overlaps. Depressed patients …
neuropsychiatric conditions with intriguing epidemiological overlaps. Depressed patients …
Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and …
The purpose of this study is to study the neuroprotective role of selective serotonin reuptake
inhibitor (SSRI), citalopram, against Alzheimer's disease (AD). Multiple SSRIs, including …
inhibitor (SSRI), citalopram, against Alzheimer's disease (AD). Multiple SSRIs, including …
[HTML][HTML] The psychonauts' world of cognitive enhancers
F Napoletano, F Schifano, JM Corkery… - Frontiers in …, 2020 - frontiersin.org
Background There is growing availability of novel psychoactive substances (NPS), including
cognitive enhancers (CEs) which can be used in the treatment of certain mental health …
cognitive enhancers (CEs) which can be used in the treatment of certain mental health …
A review: treatment of Alzheimer's disease discovered in repurposed agents
BS Appleby, D Nacopoulos, N Milano… - Dementia and geriatric …, 2013 - karger.com
Abstract Background/Aims: Many compounds that have already been approved for alternate
diagnoses have been studied in relation to Alzheimer's disease (AD). The purpose of this …
diagnoses have been studied in relation to Alzheimer's disease (AD). The purpose of this …
Sleep disturbances in Alzheimer's and Parkinson's diseases
SM Rothman, MP Mattson - Neuromolecular medicine, 2012 - Springer
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative disorders and exact a burden on our society greater than cardiovascular …
neurodegenerative disorders and exact a burden on our society greater than cardiovascular …
The neurotransmitter puzzle of Alzheimer's: Dissecting mechanisms and exploring therapeutic horizons
M Sharma, P Pal, SK Gupta - Brain Research, 2024 - Elsevier
Alzheimer's Disease (AD) represents a complex interplay of neurological pathways and
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …
molecular mechanisms, with significant impacts on patients' lives. This review synthesizes …
[HTML][HTML] Drug repositioning approaches for the discovery of new therapeutics for Alzheimer's disease
TW Kim - Neurotherapeutics, 2015 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and represents one of the
highest unmet needs in medicine today. Drug development efforts for AD have been …
highest unmet needs in medicine today. Drug development efforts for AD have been …