Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Abstract Ethnopharmacological relevance Radix Rehmanniae (RR) is the tuber root of
Rehmannia glutionsa Libosch, which was firstly recorded in Shennong's Classic of Materia …

Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

Stroke is the leading cause of disability and mortality in the world, but the pathogenesis of
ischemic stroke (IS) is not completely clear and treatments are limited. Mounting evidence …

Ischemic diseases, such as ischemic heart diseases and ischemic stroke, are the leading
cause of death worldwide. Angiogenic therapy is a wide-ranging approach to fighting …

Stroke is an acute cerebrovascular disease caused by sudden rupture of blood vessels in
the brain or blockage of blood vessels, which has now become one of the main causes of …

Stroke occurs when a cerebral blood vessel is blocked or ruptured, and it is the major cause
of death and adult disability worldwide. Various pharmacological agents have been …

Background: Subtypes of microglia/macrophage regulate the inflammation in the opposite
direction during ischemic stroke. JAK2/STAT3 signaling pathway participates in the …

The functional neural circuits are partially repaired after an ischemic stroke in the central
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …

The Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3)
signaling pathway, a well-conserved and basic intracellular signaling cascade, is mostly …