Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow …

T dos Anjos-Garcia, NC Coimbra - Psychopharmacology, 2019 - Springer
Rationale The endocannabinoid system plays an important role in the organization of panic-
like defensive behavior. Threatening situations stimulate brain areas, such as the …

Connexions between the dorsomedial division of the ventromedial hypothalamus and the dorsal periaqueductal grey matter are critical in the elaboration of …

F Ullah, T dos Anjos-Garcia, J Mendes-Gomes… - Behavioural Brain …, 2017 - Elsevier
The electrical and chemical stimulation of the dorsal periaqueductal grey matter (dPAG)
elicits panic-like explosive escape behaviour. Although neurons of the ventromedial …

CB1 cannabinoid receptor-mediated anandamide signalling reduces the defensive behaviour evoked through GABAA receptor blockade in the dorsomedial division …

T dos Anjos-Garcia, F Ullah, LL Falconi-Sobrinho… - …, 2017 - Elsevier
The effects of cannabinoids in brain areas expressing cannabinoid receptors, such as
hypothalamic nuclei, are not yet well known. Several studies have demonstrated the role of …

Enhanced anandamide signaling reduces flight behavior elicited by an approaching robo-beetle

DE Heinz, A Genewsky, CT Wotjak - Neuropharmacology, 2017 - Elsevier
Our current knowledge of the implications of endocannabinoids in fear and anxiety is largely
based on fear conditioning paradigms and approach-avoidance conflicts. Here we establish …

Nitric oxide-mediated defensive and antinociceptive responses organised at the anterior hypothalamus of mice are modulated by glutamatergic inputs from area 24b …

LL Falconi-Sobrinho… - Journal of …, 2021 - journals.sagepub.com
Background: Previous studies suggested that Cg1 area of the cingulate cortex of rats
controls glutamate-mediated fear-induced defensive behaviour and antinociception …

Antipsychotic profile of cannabidiol and rimonabant in an animal model of emotional context processing in schizophrenia

R Levin, V Almeida, F Fiel Peres… - Current …, 2012 - ingentaconnect.com
Objectives: Clinical and neurobiological findings suggest that cannabinoids and their
receptors are implicated in schizophrenia. Cannabidiol (CBD), a non-psychotomimetic …

Panic‐like responses of female Wistar rats confronted by Bothrops alternatus pit vipers, or exposure to acute hypoxia: Effect of oestrous cycle

R Ferreira‐Sgobbi, RM de Figueiredo… - European Journal of …, 2022 - Wiley Online Library
Anxiety‐related diseases are more than twice as common in women than in men, and in
women, symptoms may be exacerbated during the late luteal phase of the menstrual cycle …

Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro …

RC Almada, CM Roncon, DH Elias-Filho, NC Coimbra - Neuroscience, 2015 - Elsevier
The substantia nigra pars reticulata (SNpr) is rich in γ-aminobutyric acid (GABA)-ergic
neurons and connected to the mesencephalic tectum (MT) structures, such as the superior …

Neuroethological validation of an experimental apparatus to evaluate oriented and non-oriented escape behaviours: Comparison between the polygonal arena with a …

AF Biagioni, T dos Anjos-Garcia, F Ullah… - Behavioural Brain …, 2016 - Elsevier
Inhibition of GABAergic neural inputs to dorsal columns of the periaqueductal grey matter
(dPAG), posterior (PH) and dorsomedial (DMH) hypothalamic nuclei elicits distinct types of …

Augmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers

RC Almada, LL Falconi-Sobrinho, JA da Silva… - …, 2022 - Springer
Rationale The endocannabinoid modulation of fear and anxiety due to the on-demand
synthesis and degradation is supported by a large body of research. Although it has been …