Canabinoides ajudam a desvendar aspectos etiológicos em comum e trazem esperança para o tratamento de autismo e epilepsia

RJRM Lopes - 2014 - icts.unb.br
Desde 1843 que as propriedades anticonvulsivantes da Cannabis são conhecidas pela
ciência ocidental. Em 1980, ensaios clínicos demonstraram que canabidiol possui atividade …

Decrease in NMDA receptor-signalling activity in the anterior cingulate cortex diminishes defensive behaviour and unconditioned fear-induced antinociception elicited …

LL Falconi-Sobrinho, T dos Anjos-Garcia… - European …, 2017 - Elsevier
Acute γ-aminobutyric acid (GABA) disinhibition in the posterior hypothalamus (PH) elicits
defensive reactions that are considered anxiety-and panic attack-like behaviour, and these …

A double-blind, randomized, placebo-controlled test of the effects of cannabidiol on fear elicited by a 10% carbon dioxide-enriched air breathing challenge

EW Leen-Feldner, TM Bynion, GML Eglit… - …, 2022 - Springer
Objective A single administration of cannabidiol (CBD) can reduce anxiety during social
anxiety inductions. No study, however, has evaluated the impact of CBD on fear responding …

Anandamide in the anterior hypothalamus diminishes defensive responses elicited in mice threatened by Epicrates cenchria constrictor serpents

T Anjos‑Garcia, N Coimbra - Acta Neurobiologiae Experimentalis, 2020 - ane.pl
The purpose of this study was to investigate whether the panicolytic‑like effect of different
doses of anandamide microinjected into the anterior hypothalamus (AH) follows the same …

5-Hydroxytryptamine 2A receptors of the dorsal raphe nucleus modulate panic-like behaviours and mediate fear-induced antinociception elicited by neuronal …

R da Silva Soares Jr, LL Falconi-Sobrinho… - Behavioural Brain …, 2019 - Elsevier
It has been established that chemical stimulation of the inferior colliculus (IC) of laboratory
animals evokes fear-related defensive responses, which are considered panic attack-like …

Dissociation between the panicolytic effect of cannabidiol microinjected into the substantia nigra, pars reticulata, and fear-induced antinociception elicited by …

JA da Silva, AF Biagioni, RC Almada… - European journal of …, 2015 - Elsevier
Many studies suggest that the substantia nigra, pars reticulata (SNpr), a tegmental
mesencephalic structure rich in γ-aminobutyric acid (GABA)-and cannabinoid receptor …

[HTML][HTML] Canabidiol, um componente da Cannabis sativa, como um ansiolítico

ARM Schier, NPO Ribeiro, ACO Silva… - Brazilian Journal of …, 2012 - SciELO Brasil
OBJECTIVES: To review and describe studies of the non-psychotomimetic constituent of
Cannabis sativa, cannabidiol (CBD), as an anxiolytic drug and discuss its possible …

The endogenous opioid system modulates defensive behavior evoked by Crotalus durissus terrificus: Panicolytic-like effect of intracollicular non-selective opioid …

F Calvo, B Lobão-Soares… - Journal of …, 2019 - journals.sagepub.com
Background: There is a controversy regarding the key role played by opioid peptide
neurotransmission in the modulation of panic-attack-related responses. Aims: Using a prey …

Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB1 receptor in the ventromedial hypothalamus

AU Khan, LL Falconi-Sobrinho, T dos Anjos-Garcia… - …, 2020 - Springer
Rationale The behavioural effects elicited by chemical constituents of Cannabis sativa, such
as cannabidiol (CBD), on the ventromedial hypothalamus (VMH) are not well understood …

Sex determinants of experimental panic attacks

TA Lovick - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
Panic disorder is twice a common in women than in men. In women, susceptibility to panic
increases during the late luteal (premenstrual) phase of the menstrual cycle, when …