Cyclooxygenase-2 (COX-2) as a target of anticancer agents: A review of novel synthesized scaffolds having anticancer and COX-2 inhibitory potentialities
Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …
Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective
Innate inflammation beyond a threshold is a significant problem involved in cardiovascular
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
diseases, cancer, and many other chronic conditions. Cyclooxygenase (COX) enzymes are …
Triple targeting of mutant EGFRL858R/T790M, COX-2, and 15-LOX: design and synthesis of novel quinazolinone tethered phenyl urea derivatives for anti …
We designed and synthesised novel quinazolinone tethered phenyl urea derivatives (6a–p)
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …
that triple target the double mutant EGFRL858R/T790M, COX-2, and 15-LOX. Compounds …
Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with …
In the current study, virtual screening of a small library of 1302 pyrrolizines bearing
urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated …
urea/thiourea moieties was performed. The top-scoring hits were synthesised and evaluated …
Synthesis, biological evaluation and kinase profiling of novel S-benzo [4, 5] thiazolo [2, 3-c][1, 2, 4] triazole derivatives as cytotoxic agents with apoptosis-inducing …
A novel set of S-benzo [4, 5] thiazolo [2, 3-c][1, 2, 4] triazoles was synthesized. Cytotoxicity of
these compounds was evaluated against three cancer cell lines of different origins, Hep3B …
these compounds was evaluated against three cancer cell lines of different origins, Hep3B …
Optimization of pyrrolizine-based Schiff bases with 4-thiazolidinone motif: Design, synthesis and investigation of cytotoxicity and anti-inflammatory potency
Two new series of pyrrolizine-5-carboxamides were synthesized and evaluated for their
anticancer and anti-inflammatory activities. The new compounds exhibited potent cytotoxicity …
anticancer and anti-inflammatory activities. The new compounds exhibited potent cytotoxicity …
Antitumor activity of pyrrolizines and their Cu (II) complexes: Design, synthesis and cytotoxic screening with potential apoptosis-inducing activity
Two novel series including Schiff bases of the pyrrolizine-5-carboxamides and their Cu (II)
complexes were designed, synthesized and analysed using spectral and analytical …
complexes were designed, synthesized and analysed using spectral and analytical …
A patent review of anticancer CDK2 inhibitors (2017–present)
MA Said, MA Abdelrahman… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The success of the CDK4/6 inhibitor Ibrance™(Palbociclib) as an anticancer
agent inspired and directed more efforts toward the discovery of selective cyclin-dependent …
agent inspired and directed more efforts toward the discovery of selective cyclin-dependent …
Synthesis, characterization, pharmacological evaluation and molecular docking studies of benzothiazole azo derivatives
S Harisha, J Keshavayya, SM Prasanna… - Journal of Molecular …, 2020 - Elsevier
A series of novel benzothiazole based azo dyes were synthesized and fully characterized by
using different analytical techniques. The antioxidant activity of synthesized azo dyes was …
using different analytical techniques. The antioxidant activity of synthesized azo dyes was …
Ethyl benzoate bearing pyrrolizine/indolizine moieties: Design, synthesis and biological evaluation of anti-inflammatory and cytotoxic activities
Two new series of ethyl benzoate bearing pyrrolizine and indolizine moieties 8–11 were
synthesized and evaluated for their anti-inflammatory and anticancer activities. Among these …
synthesized and evaluated for their anti-inflammatory and anticancer activities. Among these …