Lay Summary Despite a known role for α4β7 and MAdCAM-1 for the recruitment of antibody
secreting cells to the lactating mammary gland, vedolizumab which targets integrin α4β7 did …

Introduction: At present, there is a significant amount of data related to biologics used in
pediatric patients with Crohn's disease. This review characterizes the different biological …

Inflammatory bowel disease (IBD) comprises a spectrum of chronic immune-mediated
diseases that affect the gastrointestinal tract. Onset typically occurs in early adulthood. The …

Active inflammatory bowel disease during conception and pregnancy has been associated
with adverse materno-fetal outcomes. Patients are often unduly concerned about the …

Background: Vedolizumab is a humanized immunoglobulin G1 monoclonal antibody, which
binds to α4β7 integrin on T lymphocytes, thus disturbing the interaction with mucosal …

Purpose of review This review summarizes the most current clinical research and latest
clinical guidelines in managing inflammatory bowel disease (IBD) before, during, and after …

ATAs have unique mechanisms of action and can meanwhile be considered an
indispensable column of IBD therapy. Further efforts are necessary to elucidate complex …

Idiopatické střevní záněty zahrnují Crohnovu chorobu aulcerózní kolitidu. Jsou
onemocněním převážně mladého a fertilního věku, kdy i značná část pacientek otěhotní v …

Anti-TNF-α have revolutionized the treatment of inflammatory bowel disease, but a
significant proportion of patients do not respond or lose response over time after treatment …

У дисертаційному дослідженні представлено вирішення актуальної задачі практичного
акушерства–оптимізація предиктивної діагностики та медикаментозної профілактики …