Background Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. One
of the main challenges in the management of OC is the late clinical presentation of disease …

Cancer has long been a grievous disease complicated by innumerable players aggravating
its cure. Many clinical studies demonstrated the prognostic relevance of the tumor …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Among genetic alterations in human cancers, mutations in the tumor suppressor p53 gene
are the most common, occurring in over 50% of human cancers. The majority of p53 …

Cellular senescence describes an irreversible growth arrest characterized by distinct
morphology, gene expression pattern, and secretory phenotype. The final or intermediate …

Chemotherapy is the main strategy for the treatment of cancer. However, the main problem
limiting the success of chemotherapy is the development of multidrug resistance. The …

p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell
growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its …

Cell death is a fundamental ingredient of life. Thus, not surprisingly more than one form of
cell death exists. Several excellent reviews on various forms of cell death have already been …

SR and hnRNP proteins were initially discovered as regulators of alternative splicing: the
process of controlled removal of introns and selective joining of exons through which …

One of medicinal chemistry's top priorities is the discovery of new molecules with anticancer
potential. Compounds that interact with DNA are an intriguing family of chemotherapeutic …